AstraZeneca Pharmaceuticals LP Senior Scientist/Associate Principal Scientist in Translational Science, Oncology in Waltham, Massachusetts

Senior Scientist/Associate Principal Scientist in Translational Science, Oncology

Waltham, MA

At AstraZeneca, we work together across global boundaries to make an impact and find answers to challenges. We do this with the utmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people’s exceptional skills with those of people from all over the globe

As a Senior Scientist/Associate Principal Scientist for the Clinical Translation Laboratory team in the Translational Science Department you will have the opportunity to impact AstraZeneca’s industry-leading portfolio of programs. This includes early clinical development of novel therapeutics through post-marketing opportunities that support approved targeted therapies. The Clinical Translation Laboratory has a focus on enhancing our portfolio of biomarker assays, utilizing multiplexing technologies that interrogate either RNA or proteins to enable quantification and evaluation of predictive and pharmacodynamic biomarkers in both preclinical and clinical studies.


  • Identify and deliver data on biomarkers for clinical studies based on the best available science and technologies

  • Generate disease linkage data to guide selection of tumor types and molecular segments and targeted patient populations

  • Measure target engagement reliably and quantifiably to inform clinical decisions for selecting therapeutically relevant doses and schedules

  • Interrogate clinical samples to understand mechanism of action and key oncology/immuno-oncology pathway interactions and feedback mechanisms to guide rational drug combinations

  • Evaluate and compare emerging technologies and analytical methods to identify those that generate the best data from precious clinical samples

  • Work collaboratively with colleagues to develop and implement work plans and timelines

Qualifications include:

  • A PhD in a relevant field (e.g. oncology, immuno-oncology, molecular or cell biology, immunology) with minimum 5+ years experience, preferably in industry

  • Expertise in molecular biology and cell-based techniques and assay development involving human blood and/or tissues.

  • Experience in cancer biology/immunology, including peer-reviewed publications.

  • Ability to lead from the bench in problem solving and the development of innovative solutions.

  • Excellent communication and presentation skills

AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world’s most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.

Next Steps – Apply today!

To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity. If you know someone who would be a great fit, please share this posting with them.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.