Massachusetts Veterans Jobs

MassHire JobQuest Logo

Job Information

Merck Associate Principal Scientist, DMPK Protein Therapeutics Modeling in Boston, Massachusetts

Job Description

Our company is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where our company has codified its legacy for over a century. Our company's success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.

At our company, we are inspired by the belief that a research-driven enterprise dedicated to scientific excellence can create medicines that save and improve lives. Every employee is building on our proud legacy of scientific breakthrough. Our ability to impact the lives of patients worldwide depends on the integrity, creativity, humility and scientific acumen of our team. We are creating a diverse organization that is inspired by invention and founded on a culture of respect and collaboration. At our company's Research Labs Boston, you’ll have the opportunity to expand your knowledge and skills through collaboration with talented and dedicated colleagues while advancing your career.

The Pharmacokinetics, Dynamics, Metabolism and Bioanalytics (PDMB) group is seeking a dynamic, strategic thinking and collaborative Associate Principal Scientist to contribute to our company's modeling and simulation capabilities for small molecule, peptide and protein therapeutic drug discovery and early clinical development efforts. This position will be based at our research labs in Boston, MA. The ideal candidate will contribute to collaborative PDMB modeling and simulation efforts as a translational PK/PD subject matter expert, regularly interacting with multi-disciplinary discovery teams and partners from other functions within our company. Therapeutic area support with focus on our immunology and oncology portfolios, with the potential to contribute to cardiovascular/metabolic, neuroscience and infectious disease efforts as well. The successful candidate will be expected to represent PDMB on cross-functional teams through generation and interpretation of translational modeling and simulation strategies as well as through effective communication at both internal meetings and external conferences.

In this exciting position, your primary roles will include:

  • Incorporation of in vitro and in vivo data into systemic models of drug disposition, pharmacodynamics and efficacy in support of translational and reverse translational pharmacology efforts across multiple modalities and therapeutic areas

  • Design and optimization of novel model structures utilizing state-of-the-art modeling software to understand the impact of drug disposition on novel disease biology and pharmacological response (PK/PD) with an aim of informing on human PK and dose projections

  • Close collaboration with Discovery and Early Development project teams in Boston (MA), South San Francisco (CA) and West Point (PA) aimed at building highly efficient modeling and simulation strategies to identify and optimize drug candidates

Education Minimum Requirement

  • Ph.D (with 3+ years relevant experience), Master’s (minimum of 6 years relevant experience), or Bachelor's (minimum of 10 years of experience) degree in biochemistry, chemistry, pharmacology, pharmaceutical sciences, biomedical engineering or related field

  • Relevant experience to include a record of increasing responsibility and independence in a similar industrial/academic setting

Required Experience and Skills

  • Experience contributing to development, execution, and fostering of translational and/or reverse translational pharmacokinetic-pharmacodynamic/efficacy relationships and other useful quantitative pharmacology applications in a discovery or development

  • Hands-on experience with translational pharmacokinetic/pharmacodynamic/efficacy and physiologically-based pharmacokinetic (PBPK) software modeling (e.g., Phoenix WinNonlin, Berkeley Madonna, MATLAB, etc

  • Technical ability to analyze, interpret and provide context around data describing the pharmacokinetic and pharmacodynamic properties of novel therapeutics, ensuring relevance to known or emerging biology around a given drug target

  • Strong leadership, interpersonal, communication, problem solving and collaborative qualities to deliver high quality results in a fast-paced environment

Preferred Experience and Skills

  • Expertise in biologics/large molecule/protein therapeutics DMPK modeling

  • Proven track record supporting immunology or oncology-based programs with experience spanning from early discovery through IND-enabling efforts

  • Experience collaborating within a team that spans multiple sites and functional areas

  • Experience working within a research-driven pharmaceutical company


In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separationpackage, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.


Employees working in roles that the Company determines require routine collaboration with external stakeholders, such as customer-facing commercial, or research-based roles, will be expected to comply not only with Company policy but also with policies established by such external stakeholders (for example, a requirement to be vaccinated against COVID-19 in order to access a facility or meet with stakeholders). Please understand that, as permitted by applicable law, if you have not been vaccinated against COVID-19 and an essential function of your job is to call on external stakeholders who require vaccination to enter their premises or engage in face-to-face meetings, then your employment may pose an undue burden to business operations, in which case you may not be offered employment, or your employment could be terminated. Please also note that, where permitted by applicable law, the Company reserves the right to require COVID-19 vaccinations for positions, such as in Global Employee Health, where the Company determines in its discretion that the nature of the role presents an increased risk of disease transmission.

Current Employees apply HERE ($6687.htmld)

Current Contingent Workers apply HERE ($4020.htmld)

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here ( if you need an accommodation during the application or hiring process.

We are an Equal Opportunity Employer, committed to fostering an inclusive and diverse workplace. All qualified applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status, or other applicable legally protected characteristics. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

EEOC Know Your Rights (

EEOC GINA Supplement​

Pay Transparency Nondiscrimination (

We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.

Learn more about your rights, including under California, Colorado and other US State Acts (

U.S. Hybrid Work Model

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, generally Tuesday, Wednesday and either Monday or Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence. This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.

Search Firm Representatives Please Read Carefully

Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:




VISA Sponsorship:


Travel Requirements:


Flexible Work Arrangements:



Not Indicated

Valid Driving License:


Hazardous Material(s):


Job Posting End Date:


*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Job Posting End Date: 07/31/2024

A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Requisition ID: R302615