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Merck Postdoctoral Research Fellow – Chemical Biology, Chemoproteomics in Boston, Massachusetts

Job Description

Be a part of the legacy: Postdoctoral Research Fellow Program

Our Research Laboratories’ Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.

What You'll Be Doing:

You will work with a highly collaborative and interdisciplinary team of scientists at the interface of systems biology, pharmacology, chemistry and informatics. You'll have access to a state-of-the-art mass spectrometry facility, as well as resources for cell culture, protein production and compound synthesis. The research project aims to develop novel activity-based protein profiling methods with particular focus on oncology-related biological contexts. Results will enable design of new ligands for proteins previously thought to be “undruggable”.

Responsibilities include but are not limited to:

  • Design of novel activity-based probes and coordinate synthesis with medicinal chemistry colleagues

  • Coordinate with colleagues from Protein Production group for recombinant protein generation

  • Proteomic sample preparation for profiling the reactivity of novel activity-based probes in cancer cell lines

  • Application of discovery mass spectrometry to record proteomic datasets

  • Mammalian cell culture for protein profiling experiments and validation efforts

  • Manuscript preparation, publication and presentation of results at scientific conferences

What You Need:

  • Candidates must currently hold a PhD OR receive a PhD by fall of 2021.

  • Experience in design and synthesis of small molecule protein ligands

  • Excellent understanding of chemical reactivity

  • Basic knowledge of principles of high-performance liquid chromatography and mass spectrometry

  • History of publication in peer-reviewed journals

It's Great If You Have:

  • Experience with crystal structure visualization and ligand docking software

  • Background in oncology

  • Experience in proteomic sample preparation, LC-MS/MS operation and/or data analysis

  • Experience in cloning, cell culture and protein purification

  • Standard molecular biology techniques (Western Blot, SDS-PAGE, etc.)

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” and that great medicines can make a significant impact to our world. And we believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are …

We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for …

In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth .





US and Puerto Rico Residents Only:

If you need an accommodation for the application process please email us at

For more information about personal rights under Equal Employment Opportunity, visit:

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EEOC GINA Supplement​ (

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We are an equal opportunity employer, Minority/Female/Disability/Veteran – proudly embracing diversity in all of its manifestations.

Search Firm Representatives Please Read Carefully

Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

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Requisition ID: R94393