Merck Postdoctoral Research Fellow – Chemical Biology, Chemoproteomics in Boston, Massachusetts
Be a part of the legacy: Postdoctoral Research Fellow Program
Our Research Laboratories’ Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.
What You'll Be Doing:
You will work with a highly collaborative and interdisciplinary team of scientists at the interface of systems biology, pharmacology, chemistry and informatics. You'll have access to a state-of-the-art mass spectrometry facility, as well as resources for cell culture, protein production and compound synthesis. The research project aims to develop novel activity-based protein profiling methods with particular focus on oncology-related biological contexts. Results will enable design of new ligands for proteins previously thought to be “undruggable”.
Responsibilities include but are not limited to:
Design of novel activity-based probes and coordinate synthesis with medicinal chemistry colleagues
Coordinate with colleagues from Protein Production group for recombinant protein generation
Proteomic sample preparation for profiling the reactivity of novel activity-based probes in cancer cell lines
Application of discovery mass spectrometry to record proteomic datasets
Mammalian cell culture for protein profiling experiments and validation efforts
Manuscript preparation, publication and presentation of results at scientific conferences
What You Need:
Candidates must currently hold a PhD OR receive a PhD by fall of 2021.
Experience in design and synthesis of small molecule protein ligands
Excellent understanding of chemical reactivity
Basic knowledge of principles of high-performance liquid chromatography and mass spectrometry
History of publication in peer-reviewed journals
It's Great If You Have:
Experience with crystal structure visualization and ligand docking software
Background in oncology
Experience in proteomic sample preparation, LC-MS/MS operation and/or data analysis
Experience in cloning, cell culture and protein purification
Standard molecular biology techniques (Western Blot, SDS-PAGE, etc.)
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What we look for …
In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth .
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Number of Openings:
Requisition ID: R94393
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