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Beth Israel Lahey Health Research Assistant 2 in Boston, Massachusetts

When you join the growing BILH team, you're not just taking a job, you’re making a difference in people’s lives.

Job Type:

Regular

Scheduled Hours:

40

Work Shift:

Day (United States of America)

Job Summary:

The BIDMC Functional Genomics and Bioinformatics core (FGC) is housed at BIDMC within the labs of Evan Rosen (http://evanrosenlab.com) and Linus Tsai (www.tsailab.com). The purpose of this core is to provide next generation sequencing services to investigators within FGC and the Boston area looking to expand their research capabilities. We utilize cutting-edge next generation technologies and sequencing platforms to better understand the genetic, epigenetic, and tissue/cell type bases of metabolic disease. In particular, the Rosen/Tsai labs study the biological circuits and gene regulatory networks underlying obesity and type 2 Diabetes in human and rodent models. Our labs and core provide a vibrant research environment with close links to top academic institutions and hospitals across the Boston area and provides the potential for contributions to be used and recognized worldwide. We are currently seeking a talented, motivated research assistant with a background in next generation sequencing library construction to join our team to perform ChIP-seq, RNA-seq, ATAC-seq, and single cell/nucleus RNA-seq experiments.

Job Description:

OVERALL RESPONSIBILITY

The individual will work under guidance of Drs. Rosen and Tsai to conduct bench level experiments to support 1) ongoing core projects from FGC clients (RNA-seq, ChIP-seq, ATAC-seq) and 2) development and execution of ongoing single cell RNA-seq production work in adipose tissue from mouse and human samples.

Essential Responsibilities:

Perform nucleic acid extractions and amplifications from clinical and research samples.

Perform standard molecular biological techniques, including PCR, RT-PCR

RNA-seq, ChIP-seq, ATAC-seq, CUT&RUN/CUT&Tag NGS library construction

Generation of single cell and single nucleus libraries by Drop-seq/10X genomics platforms

Operate and maintain laboratory equipment

Prepare, order, and maintain stocks of necessary reagents, solutions and supplies

Record experimental designs, results, and conclusions in both electronic and paper format. Prepare summary reports.

Troubleshoot as necessary and identify areas for improvement.

Consult with other senior scientists or scientific literature as needed. Maintain contact with target vendors for new products, applications, or product issues.

Required Qualifications:

Bachelor's degree required in Degree in science-related discipline preferred.

1-3 years related work experience required.

OR MS with requisite knowledge/skills.

Preferred Qualifications:

A minimum of one year of experience in a high throughput sequencing library construction (e.g. ChIP-seq, RNA-seq, ATAC-seq, bisulfite and DNA sequencing)

Expertise and good knowledge of RNA technique

Working knowledge of computers and databases within a Windows/Mac environment.

Strong critical thinking and analytical skills including basic data analysis.

Must demonstrate initiative in continuous technical advancement.

Ability to handle a variety of tasks amid shifting priorities.

Strong attention to detail, excellent organization and time management skills.

Excellent communication skills and the ability to work as part of a multi-disciplinary team.

Expertise and good knowledge of next-generation sequencing.

Ability to work independently, good organizational skills, attention to detail, the ability to multi-task, and good communication skills are required.

Must possess a high level of initiative and the ability to work with a moderate level of supervision.

Highly preferred (not required) research experience includes: FACS sorting, liquid handler experience, single cell RNA-seq, protocol development.

Competencies:

Written Communications: Ability to summarize and communicate in English moderately complex information in varied written formats to internal and external customers.

Oral Communications: Ability to comprehend and communicate complex verbal information in English to medical center staff, patients, families and external customers.

Knowledge: Ability to demonstrate full working knowledge of standard concepts, practices, procedures and policies with the ability to use them in varied situations.

Team Work: Ability to work collaboratively in small teams to improve the operations of immediate work group by offering ideas, identifying issues, and respecting team members.

Customer Service: Ability to provide a high level of customer service and staff training to meet customer service standards and expectations for the assigned unit(s). Resolves service issues in the assigned unit(s) in a timely and respectful manner.

Physical Nature of the Job:

Light work: Exerting up to 20 pounds of force frequently to move objects. Some elements of the job are sedentary, but the employee will be required to stand for periods of time or move through out the hospital campus

FLSA Status:

Non-Exempt

As a health care organization, we have a responsibility to do everything in our power to care for and protect our patients, our colleagues and our communities. Beth Israel Lahey Health requires that all staff be vaccinated against influenza (flu) and COVID-19 as a condition of employment. Learn more (https://www.bilh.org/newsroom/bilh-to-require-covid-19-influenza-vaccines-for-all-clinicians-staff-by-oct-31) about this requirement.

More than 35,000 people working together. Nurses, doctors, technicians, therapists, researchers, teachers and more, making a difference in patients' lives. Your skill and compassion can make us even stronger.

Equal Opportunity Employer/Veterans/Disabled

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