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CRISPR Therapeutics Research Associate-Principal Research Associate, LNP Delivery (Multiple Openings) in Boston, Massachusetts

Company Overview

CRISPR Therapeutics is a leading gene editing company focused on developing transformative gene-based medicines for serious diseases using its proprietary CRISPR/Cas9 platform. CRISPR/Cas9 is a revolutionary gene editing technology that allows for precise, directed changes to genomic DNA. CRISPR Therapeutics has established a portfolio of therapeutic programs across a broad range of disease areas including hemoglobinopathies, oncology, regenerative medicine and rare diseases. To accelerate and expand its efforts, CRISPR Therapeutics has established strategic partnerships with leading companies including Bayer, Vertex Pharmaceuticals and ViaCyte, Inc. CRISPR Therapeutics AG is headquartered in Zug, Switzerland, with its wholly-owned U.S. subsidiary, CRISPR Therapeutics, Inc., and R&D operations in Boston, Massachusetts and San Francisco, California, and business offices in London, United Kingdom.

Position Summary

CRISPR Therapeutics is seeking Research Associates to help with the development of LNP systems for in-vivo mRNA and gRNA delivery to support in vivo and immuno-oncology programs. A successful candidate will support the execution of characterization assays LNP batches. The position requires enthusiasm, passion, attention to detail and a desire to join a growing team to build formulation at LNP at CRISPR Therapeutics.


  • Assist in the lipid nanoparticle formulation process

  • Formulate RNAs and plasmids to support company’s in vivo and immuno-oncology programs

  • Perform routine analytical testing to characterize formulations in stability studies

  • Maintain thorough and detailed electronic lab notebooks and documentation records

  • Adhere to all laboratory safety requirements and procedures

  • Assist in maintaining general laboratory functionality, including lab equipment maintenance and the ordering and receiving of lab supplies

Minimum Qualifications

  • BS/MS in Chemistry, Chemical Engineering, Bioengineering, Pharmaceutical Sciences or related discipline

  • Industry Experience

  • Research Associate I –  0-2 years

  • Research Associate II – 2-4 years or 0-2 years with advanced degree

  • Senior Research Associate – 4-7 years or 2-5 years with advanced degree

  • Principal Research Associate – 6-10 years or 4-8 years with advanced degree

  • Knowledge of process scale up/scale down

  • Excellent oral and written communication skills

  • Track record of intellectually challenging oneself to enhance scientific capabilities

  • Ability to work independently as well as part of a results-oriented research team; highly organized with significant attention to detail

Preferred Qualifications

  • Knowledge of GMP and GLP regulations

  • Knowledge of nucleic acid chemistry and biology


  • Collaborative – Openness, One Team

  • Undaunted – Fearless, Can-do attitude

  • Results Orientation – Delivering progress toward our mission. Sense of urgency in solving problems.

  • Entrepreneurial Spirit – Proactive. Ownership mindset.

CRISPR Therapeutics, Inc. is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law.

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