Massachusetts Veterans Jobs

MassHire JobQuest Logo

Job Information

Alexion Pharmaceuticals Senior Director, Strategy, Program and Portfolio Management in Boston, Massachusetts

Position Summary

The Head, SPPM - TA is responsible for overseeing the planning, execution, and decision-making processes of the Global Program Teams in support of Company’s product development and lifecycle, within the respective TA.

The Head, SPPM - TA partners with the clinical Therapeutic Area Head (TAH) who manage both the Global Medicine Team Leaders (GMTL) and the Global Program Team Leaders (GPTL), respectively.

The Head, SPPM - TA collaborates with the Clinical Therapeutic Area Head (TA Head) and VISion Lead in advancing the Therapeutic Area/ disease area strategy and the portfolio of drug development programs in the most efficient and effective way. The Head, SPPM - TA may be required to manage key therapeutic area drug development activities and processes while providing cross-functional program management leadership.

The Head, SPPM - TA is the strategic partner of the TA head and Vision Lead in establishing the Disease area strategy, goal setting and portfolio oversight. The Head SPPM - TA also partners with the TA/VISion Leadership Team, as it relates to strategic planning, portfolio prioritization; brand planning, launch execution and identification and assessment of new pipeline/commercial assets.

The Head, SPPM - TA ensures effective communication to key stakeholders of the TA; facilitates and manages the TA/VISion Strategy Team and the TA Forum (if required) meetings; provides expertise in risk management at a Medicine and Program Team and TA/VISion level.

The Head, SPPM - TA manages a team of Global Program Mangers (GPMs) who partner with Global Medicine Leads (GMTL) and Global Program Team Leads (GPTL) and their respective GMTs/GPTs. The GPMs are responsible for robust and balanced cross-functional program planning (timeline and budget), execution, monitoring, and reporting to ensure strong cross functional alignment between Product/ Lifecycle strategy and operational execution by the GPTs and sub-teams. The Head, SPPM -

TA also works to ensure the cross-functional teams operate effectively, drive decision- making and issue resolution and adhere to the Company Product Operating Model and respective procedures. Together with the R&D Portfolio Management Operations team they support the teams to drive positive team dynamics.

This senior leadership position is responsible for overseeing the respective TA GPM team, accountable to develop and implement world-class project/program management capabilities. The Head, SPPM - TA is accountable to develop and train staff who drives PM excellence in development, registration, launch and access of commercially viable products.


  • Serve as the strategic partner for TA Head and VISion Lead to deliver on Alexion’s pipeline and lifecycle portfolio and to lead, develop, coach and/or mentor a team of aligned GPMs.

  • In addition, the Head, SPPM - TA must be able to provide both strategic support to the TAH and VISion Lead and help the teams to develop integrated plans to successfully execute the strategy. The successful delivery of goals and milestones ties to the overall longevity of Alexion’s pipeline and commercial portfolio.

  • Detailed responsibilities as the Head, SPPM - TA:

  • Participate in and drive cross-functional, strategic business planning and flawless execution against set goals.

  • Tracks relevant program KPIs and proactively identifies issues and work on mitigation plans

  • Ensure flawless execution & continuous monitoring of therapeutic area strategy progress, goals, metrics, program -related decisions and major milestones; ensure action items are completed and decisions are implemented. Elevate program & process related issues as necessary to TA Head and to the Head SPPM, respectively and other appropriate functional leaders

  • Provide oversight to SPPM interactions with external business partners and alliances

  • Mentor, and guide GPMs, GMTs/GPTs in improving accuracy and transparency in team communications, navigating governance, delivery on program tasks and rigorous decision-making processes; driving stage gate reviews and reporting

  • Partner with Clinical TA Head, VISion Lead and R&D Portfolio Management Operations, to drive accurate and transparent business reporting. Maintains deep knowledge on internal processes/requirements to deliver products to patients, and is an objective sounding board, providing advice and guidance

  • Facilitate/manage strategy, TA portfolio review, cross-functional operational reviews and Therapeutic Area Strategy meetings – set agendas, write minutes, review presentations. Ensure escalation of key issues

  • Synthesis of TA key program portfolio data providing consolidated updates to Executive Management. Develop and deliver key messaging and presentations for the Head SPPM, TA head, Vision lead (presentation/information delivered to DCSC and Sr Leadership as required eg Board of Directors, Investor Relations, other senior teams, and external events). Accountable for management/delivery of senior management ad-hoc requests to support informed decision making.

  • Partner with TA Head to drive activities that help consolidate and cross-fertilize knowledge and expertise within the TA, internally and externally (e.g. TA off- sites, TA forums, TA pipeline presentation, TA strategic ad boards with external KOLs or stakeholders in preparation of the TA strategic plans, etc.)

  • Represent the Head SPPM at selected meetings and participates in SPPM LT and other meetings as required. Attend relevant governance and steering committee meetings to provide cross- program input in support of the product strategy and execution.

  • Monitor Program Goals and Scorecard and overall pipeline progress (timeline/budget) and provides performance updates to stakeholders. Conduct in-depth strategic analysis of key program issues in preparation for senior management reporting. Validate senior management reports with key stake holders and SPPM team. Ensure appropriate program documentation.

  • Partner with Finance to ensure budget optimization for programs and facilitate discussions and reviews of FTEs / resource needs / capacity through interfacing with capacity planning and finance representatives, and through periodic assessments together with the Head SPPM and the TA Head.

  • Work closely with Head SPPM and R&D Portfolio Management Head to identify and contribute to departmental process improvements & initiatives

  • Recruit, manage, motivate, develop and mentor staff members. Monitor & assess team effectiveness at both the team & individual levels

% of Time

Job Function and Description


Program Management oversight - GMT/GPT and GPM Operations, Pipeline/Inline products, Reporting, Governance


Global Program Management staff – oversight, development


TA/VISion and TA Strategic Leadership Support

Education and Experience Requirements

  • Master’s degree in life sciences or related field required; MS or MBA

  • Strong business acumen

  • Minimum of 15+ years of experience in pharmaceutical drug development and/or commercialization of branded drug products demonstrated success leading multi- site, global or enterprise-wide programs in the biotech/pharmaceutical industry

  • Minimum of 10 years direct experience in different therapeutic areas

  • Minimum of 10 years of experience in cross-functional program/ project management in the pharmaceutical environment

  • Demonstrated experience in most stages of development and lifecycle (pre-clinical through post launch)

  • Knowledgeable in at least one functional area (proven experience); has to be able to assess validity of overall program/project strategy and deliverables

  • Proven Leader with ability to manage multiple complex cross-functional teams and processes in a fast-paced environment

  • Training, coaching and leadership experience

  • Experience with direct management of professional staff required

  • Project Management Professional (PMP) certification or equivalent proficiency a plus

  • Strong knowledge and understanding of global drug product development

  • Experience facilitating/ leading multi-disciplinary teams.

  • Strong understanding and competency in planning processes and decision-making

  • Demonstrated experience using standard program management tools and software

  • including integrated development plans, timelines, risk management, and budget development and monitoring.

Additional Qualifications

  • High level of accountability

  • Exceptional ability to manage multiple tasks/projects in a fast-paced matrix environment, with changing priorities and significant time pressures.

  • Strong listening, presentation and communication skills, have poise in complex/ambiguous situations

  • Strong interpersonal skills to influence people at all levels of the organization without authority, including negotiation of competing priorities, managing meetings and group dynamics, ability to balance concerns of line management with objectives of cross- functional team

  • Proven leadership capabilities with ability to establish and motivate staff and teams, empower team members, build relationships, coach, inspire, supervise and develop others in complex matrix environment.

  • Strong ability to manage and resolve complex strategic and operational issues, provide insight into complex multi-functional interdependencies and interactions between programs and to translate strategies into tangible (time/resources) deliverables for team to execute.

  • Strong analytical and decision-making ability, including ability to synthesize complex and diverse inputs to a problem, and recommend solutions/preferred options

  • Excellent communication skills, including: executive level written and oral recommendations and communications

  • Self-starter with leadership skills requiring minimum oversight who is pro-active, motivates, and has tact, diplomacy and is a true team player.

  • Ability to adapt quickly and well to change, both organizationally and culturally

  • Fluency (spoken and written) in English


[[filter5]], [[filter1]]


Some opportunities happen only once in a lifetime - like a job where you have the extraordinary opportunity to change lives. At Alexion, such opportunities arise through our unwavering mission to serve patients and families affected by rare diseases. These patients are our guiding star, and we act with integrity, urgency, and discipline because we know their lives are at stake.

Alexion is a global biopharmaceutical company focused on serving patients and families affected by rare diseases and devastating conditions through the discovery, development and commercialization of life-changing medicines. As a leader in rare diseases for more than 25 years, Alexion has developed and commercializes two approved complement inhibitors to treat patients with paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS), as well as the first and only approved complement inhibitor to treat anti-acetylcholine receptor (AchR) antibody-positive generalized myasthenia gravis (gMG) and neuromyelitis optica spectrum disorder (NMOSD). Alexion also has two highly innovative enzyme replacement therapies for patients with life-threatening and ultra-rare metabolic disorders, hypophosphatasia (HPP) and lysosomal acid lipase deficiency (LAL-D) as well as the first and only approved Factor Xa inhibitor reversal agent. In addition, the company is developing several mid-to-late-stage therapies, including a copper-binding agent for Wilson disease, an anti-neonatal Fc receptor (FcRn) antibody for rare Immunoglobulin G (IgG)-mediated diseases and an oral Factor D inhibitor as well as several early-stage therapies, including one for light chain (AL) amyloidosis, a second oral Factor D inhibitor and a third complement inhibitor. Alexion focuses its research efforts on novel molecules and targets in the complement cascade and its development efforts on the core therapeutic areas of hematology, nephrology, neurology, metabolic disorders and cardiology. Headquartered in Boston, Massachusetts, Alexion has offices around the globe and serves patients in more than 50 countries. Further information about Alexion can be found at:

As a leading employer in our industry, Alexion is proud to offer a highly competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, 401(k) with company match, tuition reimbursement, relocation assistance and much more.