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Massachusetts Institute of Technology Postdoctoral Associate, Niles Lab in Cambridge, Massachusetts

Postdoctoral Associate, Niles Lab

  • Job Number: 21823

  • Functional Area: Research - Scientific

  • Department: Department of Biological Engineering

  • School Area: Engineering

  • Employment Type: Full-Time

  • Employment Category: Exempt

  • Visa Sponsorship Available: Yes

  • Schedule:

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    Job Description

POSTDOCTORAL ASSOCIATE, Biological Engineering, Niles Lab ( , to conduct research applying advanced genetic technologies in malaria drug discovery projects. Projects will seek to establish early-stage genetic and chemical validation for selected targets, towards prioritization into drug discovery pipelines. Will use CRISPR/Cas-based genome editing tools to create and characterize transgenic malaria parasites; develop and implement phenotypic and other functional assays toward advancing the sophistication with which novel targets and chemical leads can be rapidly identified; participate in and/or lead basic biological studies to advance fundamental understanding of novel targets on a case-by-case basis using a range of molecular biology, genetics, biochemistry, cell biology, and ‘omics (RNA-seq, metabolomics and proteomics) approaches; and perform other tasks. The full position description may be found here ( .

Job Requirements

REQUIRED: Ph.D. in biological/life science field, genetic engineering, or a closely related field; interest in malaria research; direct experience using genome editing tools to create and validate transgenic organisms using various molecular, cellular, and biochemical methods; experience developing quantitative assays (broadly defined), and quantitative analysis of dose-response assays done in moderate to high throughput; leadership skills for conducting collaborative research within the lab and with collaborators; and ability to initiate new projects/experiments while working independently and as part of a team on time-sensitive, milestone-driven projects. PREFERRED: at least two years of experience studying malaria or another protozoan parasite biology or bacterial/fungal pathogens, proficiency with basic microbiology and molecular biology (PCR, cloning, western blot, etc,), and direct experience using next-generation sequencing in quantitative assays. Job #218239/9/22