Merck Postdoctoral Research Fellow – Vaccine Immunology and Immune Regulation in Cambridge, Massachusetts
Be a part of the legacy: Postdoctoral Research Fellow Program
Our Research Laboratories’ Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.
What You'll Be Doing:
As a postdoctoral fellow in our Research Laboratories you will work with a highly collaborative team of scientists at the Exploratory Science Center at Cambridge, MA to uncover immune regulation and mechanisms that result in specific and non-specific vaccine responses. The Exploratory Science Center provides a unique experience to contribute to our drug discovery efforts at the earliest stages of the process. To this end, we strive to create a fast-paced, nimble and flexible environment of creativity, invention and teamwork. This position will provide a unique opportunity to be exposed to cellular and molecular immunology and infectious disease research both within the Exploratory Science Center and across other sites. With access to our proven global R&D organization, you’ll have the opportunity to collaborate with talented and dedicated colleagues while developing and expanding your career.
You will focus on deciphering various vaccine mechanism of action, effects on innate immune memory and outcome on host health in infection models.
Responsibilities include but are not limited to:
Demonstrate deep scientific and technical expertise to advance our understanding of vaccine effects on innate and adaptive immune memory.
Plan, design and execute experiments using animal models for vaccine evaluation.
Leverage the breadth of expertise and resources available across the organization.
Employ targeted cellular and molecular biology techniques to dissect in-vivo observations and uncover underlying mechanisms.
Identify and test novel signatures using in vitro and in vivo systems and generate novel therapeutic angles for future research and development that ultimately contribute to next generation vaccines.
Maintain experimental records in an electronic notebook, communicate findings to multidisciplinary teams, produce high-impact publications and present at scientific conferences
What You Need:
Candidates must currently hold a PhD OR receive a PhD by fall of 2021. Degree should be in Immunology or a related field.
Skills in one or more of the following areas: Immunology, Vaccinology, immune modulation and regulation, Infectious Diseases.
Experience working with innate, adaptive immune cells, and use of murine models to study vaccine response
Experience in flow cytometry based read outs, deep understanding and analyses of metabolomics and transcriptomics datasets.
Ability to independently design experiments, interpret, communicate complex scientific data and deliver results in a timely manner
Excellent record keeping and organizational skills.
It's Great If You Have:
Isolation & characterization of immune cell subsets from various tissues.
Designing & executing multi-parameter FACS panels, including single cell sorting.
Skilled in sequencing library preparation: ChIP-Seq, RNA-seq, ATC-Seq and other relevant techniques
Knowledge of molecular and cellular immunology and/or animal models.
Strong history of publication in top-tier, peer-reviewed journals
We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” and that great medicines can make a significant impact to our world. And we believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.
Who we are …
We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.
What we look for …
In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth .
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Number of Openings:
Requisition ID: R89328
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