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CRISPR Therapeutics Research Associate II, Oligonucleotide Purification, Non-Viral Delivery in Cambridge, Massachusetts

Company Overview

At CRISPR Therapeutics, we are focused on developing transformative gene-based medicines for serious human diseases. We are rapidly translating our CRISPR/Cas9 gene editing platform into therapies to treat hemoglobinopathies, cancer, diabetes, and other diseases. Our multi-disciplinary team of world-class researchers and drug developers is committed to translating CRISPR/Cas9 technology into breakthrough human therapeutics. Our lead program targeting the blood diseases β-thalassemia and sickle cell disease has entered clinical testing, and our immuno-oncology programs focused on CRISPR/Cas9-edited allogeneic CAR-T cell therapies have the potential to deliver the next generation of cancer therapies to patients.

Job Summary

We are seeking a highly motivated Research Associate to join our Non-viral Delivery team and help expand our capabilities in the production of therapeutic oligonucleotides. The successful candidate will apply their knowledge of chromatographic separation techniques to the purification of chemically synthesized deoxyoligonucleotides and guide RNAs. This position with support cross-functional efforts in multiple therapeutic areas (Hematology, Immuno-oncology, and Regenerative Medicine) as well as the development of our non-viral delivery platform.


  • Develop, optimize, and troubleshoot purification processes for a rapidly expanding pipeline of novel oligonucleotide therapies

  • Apply standard chromatographic methods (e.g., IEX, HIC, and reversed-phase) and ultrafiltration/diafiltration for the purification of oligonucleotides at a preparative scale

  • Investigate the utility of emerging purification technologies for the purification of oligonucleotides with novel chemistries

  • Ensure proper operation and maintenance of AKTA and Gilson purification systems

  • Maintain an accurate and up-to-date record of experiments and results in the form of ELN entries and written reports

  • Communicate key findings in group and cross-functional team meetings

  • Contribute to regulatory and IP filings

Minimum Qualifications

  • MS degree in Chemistry, Chemical Engineering, Biochemistry, Bioengineering or related field, or BS degree in a similar field and 3+ years of relevant experience

  • Hands-on experience with the purification of nucleic acids and/or proteins by conventional column chromatography (e.g., IEX, HIC, SEC and/or reversed-phase)

  • A working knowledge of analytical methods required to support the development of nucleic acid-based therapies

  • Demonstrated technical proficiency in the development and optimization of purification methods

  • An educator’s mindset with an eagerness to invest in communication with scientists and senior leaders, and a passion scientific engagement with colleagues

  • A learner’s mindset with a commitment to personal growth and a drive to broaden technical skills and scientific knowledge

  • The ability to think strategically, efficiently manage time and workflows, and work both independently and collaboratively in a cross-functional team environment

Preferred Qualifications

  • Hands-on experience with ultrafiltration/diafiltration systems

  • Experience with analytical HPLC/UPLC systems

CRISPR Therapeutics, Inc. is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law.

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