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Bristol Myers Squibb Scientist - Analytical Development & Attribute Science in Cambridge, Massachusetts

At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

Scientist - Analytical Method Development

Description:

Bristol-Myers Squibb is a global biopharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help patients prevail over serious diseases.

One shared journey is moving us forward at Bristol-Myers Squibb. Around the world, we are passionate about making an impact on the lives of patients with serious disease. Empowered to apply our individual talents and ideas so that we can learn and grow together. And driven to make a difference, from innovative research to hands-on community support. Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.

The expansion of the large-scale biologics manufacturing facility has created a mammalian cell biologics center of excellence through the introduction of biologics development and clinical trial manufacturing capabilities to the site.

The Scientist will be working within the Biologics Development (BD) organization. The role will involve the development, qualification and transfer of analytical separation methods used for product release, stability study and process characterizations supporting late phase programs. The successful candidate should be self-motivated, have excellent communication skills, be a team player, and have knowledge and experience in protein chemistry and bioanalytical techniques including chromatographic and electrophoretic separations. Desired skills include Design of Experiment (DoE), HPLC/UPLC, LC-MS, Capillary Electrophoresis, SDS-PAGE, as well as biophysical characterization and biological techniques. Knowledge and experience with protein / peptide characterization and molecular and cell biology would be a plus.

This role will be located in Cambridge, MA.

Responsibilities:

  • Develop, qualify, transfer and characterize bio-analytical techniques for monoclonal antibodies, recombinant proteins and Advanced Therapy Medicinal Products (ATMPs) to support product release, stability and process characterization studies under targeted timelines. Author method SOPs, development and qualification reports.

  • Provide training and oversight of assay performance to testing labs including CROs.

  • Work collaboratively across organization and sites for method readiness, transfer, performance and trouble shooting supporting late phase development projects.

  • Authors and reviews analytical method and validation sections in IND filing documents

  • Train and coach junior scientists

  • Utilize statistical tools for Design of Experiment (DoE) to optimize assay conditions and evaluate assay robustness, and to analyze and trend development data.

  • Actively lead and work on internal initiatives for improvement of business processes.

  • Evaluate new technologies and lead scientific and technological innovations for process improvement.

  • Work closely with commercial development teams supporting commercial method validation and BLA filings.

Qualifications:

  • Degree in Biochemistry, Biotechnology, Analytical Chemistry, Molecular Biology, Virology, Chemical / Biological / Biochemical Engineering or a related discipline.

  • PhD with 2+ years or MS with 7+ years or BS with 10+ years relevant experience in Biotech or Pharmaceutical industry.

  • A strong background in the areas of analytical chemistry/biochemistry, with the emphasis on experience and in-depth working knowledge of CE, iCE, and HPLC/UPLC (UV/FL/CAD/MS).

  • Experience with protein fragmentation (CE-SDS, RPLC), charge variants (AEX/CEX/CIEF/iCIEF), N-glycans, peptide mapping and aggregation/HMW analysis (Size Exclusion Chromatography) techniques is highly desirable.

  • Experience with mass spectrometry and biophysical characterization is a plus.

  • Experience with PCR, ELISA, Western Blotting, Cell based bioassay is a plus.

  • Working knowledge of design of experiments and basic statistical knowledge is desirable.

  • Familiarity with biologics process and regulatory requirement for biologics development.

  • Knowledge of cGMPs as applied to analytical development and testing.

  • Development experience for both early- and late-stage programs is highly desirable.

  • Excellent communication and interpersonal skills.

  • Works independently and collaborates with other groups. Deliver results in line with project and team objectives.

Physical Demands:

  • This role requires office work, biochemical laboratory work, computer work, group meetings, and thus involves the following: sitting, standing, walking, working with analytical instruments, repetitive motion including bending and lifting small containers/equipment’s.

Work Environment

  • Working in an analytical laboratory handling chemical reagents that may be hazardous (corrosive, toxic, flammable etc.).

  • Office work, teleconferencing, computer work, leading meetings requiring working in open office environment, working alone and working with/around others.

Travel

  • This position may require occasional travel.

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.

To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to adastaffingsupport@bms.com . Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

Company: Bristol Myers Squibb

Req Number: R1548111

Updated: 2021-10-22 04:37:17.741 UTC

Location: Cambridge,Massachusetts

Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.

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