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Editas Medicine Scientist I/II, Immunology-Stem Cell Biology-Molecular Biology in Cambridge, Massachusetts

What if you could repair broken genes? That is the question we ask ourselves at Editas Medicine. We’re focused on translating the power and potential of the CRISPR/Cas9 and CRISPR/Cas12a (also known as Cpf1) genome editing systems into a robust pipeline of medicines for people living with serious diseases around the world. Our goal is to discover, develop, manufacture, and commercialize transformative, durable, precision genomic medicines for many diseases.

We’re looking for talented, dedicated, passionate people to join our team and help us pioneer this field and do big, bold things that have never been achieved before.

Are you full of hope, possibilities, and a belief that, working together, we can truly revolutionize the development of medicines to help patients around the world? If the answer is yes, then Editas Medicine is the place for you.

Editas Medicine is seeking a highly motivated Scientist I/II to join our Immunogenetics group that is generating medicines at the intersection of three exciting platforms: iPSCs, CRISPR gene editing, and immuno-oncology. The candidate will be part of a team that is responsible for identifying genomic edits that will generate iPSC-derived cell therapies with enhanced anti-tumor function. An ideal candidate should have a strong background in immunology, molecular biology, cell biology, and a strong interest in genome editing. The successful candidate will be part of a dynamic and matrixed team and will interact with many internal groups and external collaborators.

Key Responsibilities

The PhD scientist will employ his/her scientific and analytic skills to develop scientific rationale and execute iPSC gene editing experiments to achieve some of the following goals:

  • Identify optimal transgene cargo configurations and target loci to support targeted integration gene expression before, during, and after iPSC differentiation to desired effector cell types

  • Incorporate synthetic biology solutions to achieve optimal efficacy and safety in transgene knock-in cargos

  • Develop and optimize protocols and assays for gene editing in iPSCs (gene knockouts and targeted integration of functional transgene cargos)

  • Validate functionality of different indel profiles in single-cell iPSC clones and how those indels lead to optimal anti-tumor function

  • Analyze and present data within the organization

  • Share responsibility in maintaining lab equipment and reagent inventory

  • Maintain an electronic lab notebook and contribute to support documentation

Requirements

  • PhD in immunology, (stem) cell biology, or related field with 1-3 years of industry experience being a major plus, but not required

  • Proven track record of success in his/her field, the capacity to work effectively with minimal supervision and achieve goals on time. Background in immuno-oncology is a plus

  • Work cross-functionally with other teams to innovate and optimize iPSC genome engineering that integrates immune-effector cell function and tumor recognition with somatic cell reprogramming through gene editing

  • Ability to quickly assimilate new information, critically evaluate team inputs & literature data, summarize and communicate concepts/key takeaways effectively

  • Strong expertise in synthetic molecular biology (gene circuits, plasmid cloning, DNA/RNA isolation, PCR, ddPCR, etc.)

  • Strong background in mammalian cell culture and various cellular assays (ex: flow cytometry)

  • Experience with execution and/or data analysis of high-throughput genomic and transcriptomic assays like ChIP-seq, RNA-seq, etc… is highly desired

  • Experience with laboratory robotics and CRISPR are a plus, but not a requirement

  • Highly self-motivated and a strong team player with ability to work in a team-oriented multidisciplinary environment and engage in the Editas culture of “Community, Innovation, and Results”

  • Excellent oral and written communication skills to meet the needs of varied audiences.

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