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Takeda Pharmaceuticals Scientist I/II, Investigative Toxicology in Cambridge, Massachusetts

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Job Description

About the role:

The Global Investigative Toxicology team is a cross-functional team of scientists that aim to detect and de-risk toxicity in Takeda’s portfolio to help make medicines safer and more effective. We are looking for a Research Associate Scientist to support these efforts across platforms and modalities. The Research Associate Scientist will contribute ideas and deliver decision-making data to inform project teams on improved efficacy and/or de-risking of potential toxicities.

  • Work as part of a global team of safety assessment scientists to detect and de-risk toxicities associated Takeda assets.

  • Design and implement early safety assessment screening strategies to enable the progression of optimized therapeutic candidates.

  • Conduct cell-based in vitro assays to characterize toxicities for medicines in discovery & development.

  • Develop novel in vitro model systems to assess safety risks associated Takeda assets.

Join Takeda as a Scientist I/II, Investigative Toxicology, based in Cambridge, MA.

How you will contribute:


  • Develop, design, execute, and interpret in vitro cell-based assays to characterize diverse mechanisms of toxicity with a focus on rare disease and gene therapy therapeutics.

  • Maintain cultures of immortalized cancer cell lines, primary cell types of various origin (lung, liver, kidney, intestine, pancreas, blood etc.).

  • Prepare experimental protocols, analyze experimental data, and present study results in team and department meetings.

  • Contribute ideas to drive innovation within investigative toxicology and with key collaborators (e.g. pharmacology, DMPK, bioinformatics).

  • Good documentation practices are required.

Minimum Requirements/Qualifications:

  • Ph.D. with 0-2 years or MS with 6+ years or BS with 8+ years of experience in biology, biochemistry, pharmacology, or a related discipline.

  • Expert with standard aseptic cell culture technique, including experience culturing various cell types. Experience with culturing and differentiating primary cells is a plus.

  • Broad experience with cell-based functional assays. Experience with cell transfection/transduction, imaging, and flow cytometry is a plus.

  • Basic experience with molecular biology techniques including RNA/DNA extraction, qPCR, and western blot.

  • Experience working in a matrixed team environment at a pharmaceutical company and/or CRO.

  • Broad scientific knowledge in hematology, immunology, and pharmacology.

  • Self-motivated with strong time management and organizational skills.

  • Ability to balance multiple projects and flexible with changing priorities.

  • Highly collaborative with demonstrated ability to work in a matrixed team environment.

  • Excellent oral and written communication skills.

What Takeda can offer you:

  • Comprehensive Healthcare: Medical, Dental, and Vision

  • Financial Planning & Stability: 401(k) with company match and Annual Retirement Contribution Plan

  • Health & Wellness programs including onsite flu shots and health screenings

  • Generous time off for vacation and the option to purchase additional vacation days

  • Community Outreach Programs and company match of charitable contributions

  • Family Planning Support

  • Flexible Work Paths

  • Tuition reimbursement

More about us:

At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.

Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

In accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply.

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.


USA - MA - Kendall Square

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Full time