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Lilly Scientist-Neuropathology Research in Cambridge, Massachusetts

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 35,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

At the Lilly Innovation Center in Cambridge, Massachusetts, we explore how next generation therapeutics, new technologies, data analytics and new care models can improve patient health and the healthcare system. Our team in Cambridge shares a real passion for challenging conventional wisdom and creating an environment that embraces creative, break-through concepts. The Center offers a start-up environment with large company support. It is located in the heart of Massachusetts’ exploding science and technology cluster and is within walking distance of some of the best academic and industry innovators in the world.

Our Neuroscience Next Generation Therapeutics team is an innovation-focused organization striving to identify, develop and apply the most ground breaking technologies to deliver maximum benefit to our patients. Oligonucleotide-based therapies and other novel modalities represent an existing avenue of research toward development of the next generation of therapies. If you are looking to be part of a growing, driven team where you will help to progress new therapeutic approaches like these, read on!

Our team focuses on using novel therapeutic modalities to deliver medicines for chronic pain and neurodegenerative disorders. We work with internal and external partners to identify and deliver new novel therapies into patients at speed. We are seeking experienced and inspiring scientists to join our fast-paced, interdisciplinary team as we use innovative RNA/oligonucleotide/gene and genomic based therapies to enhance our portfolio.

Do you have a track record of delivering neuropathology-based outcomes with scientific curiosity and demonstrated technical expertise? Apply today and join our mission of creating life-changing medicines!

Some responsibilities in this role:

  • Lead the development, implementation, and execution of high throughput singleplex and multiplex histology assays including immunohistochemistry (IHC), immunofluorescence (IF), and RNAscope based assays

  • Develop, validate, and perform histological protein detection assays (including antibody evaluation and characterization) and other fit-for-purpose neuropathological assays

  • Perform histological lab techniques including, but not limited to tissues grossing, processing, paraffin embedding, tissue sectioning, routine and special tissue staining, and image analysis.

  • Troubleshoot technical challenges and provide scientific/technical input to project teams

  • Design, complete experiments and perform data analysis, creating draft documents and presentations.

  • Provide conceptual input to experimental design, integrated data analysis and communication of results to scientific teams and management

  • Maintain an awareness of emerging techniques and tools relevant to the field to contribute to growing the state-of-the-art neuropathology lab.

  • Provide written and verbal communication of work in lab reports and team meetings

  • Accurate recording of all practical work: completion of electronic notebook to Lilly procedure quality standards

  • General laboratory assistance, including ordering and receiving lab supplies, preparation of reagents, and maintain laboratory equipment

  • Ensure compliance with all health and safety regulations

  • Enthusiastic about contributing and leading daily at a high level in the lab

Minimum Qualifications

BSc in Neuroscience, biological sciences or related field

Additional Skills/Preferences

  • Broad, hands-on experience in tissue sectioning (including formalin fixed paraffin embedded [FFPE] and frozen tissue sectioning), immunohistochemistry, immunofluorescence, and in situ hybridization (including multiplexed formats using automated equipment [Leica]), light microscopy and fluorescence microscopy (including Aperio slide scanners)

  • Knowledge of relevant image analysis software packages: HALO, HALO-AI, ImageScope, VisioPharm, Definiens, GraphPad Prism etc.

  • Previous experience in neuroscience research and/or oligonucleotide drug discovery is strongly preferred

  • Demonstrated experience in processing, organizing, analyzing, and visualizing neuropathology based outcomes and ability to extract insight from data

  • Proven ability to design, complete and interpret experiments independently, and to advance scientific understanding.

  • Ability to adapt and exercise flexibility for changing platform needs, workflows and projects.

  • Excellent communication skills and demonstrated efficiency in collaborating across functional boundaries.

  • Strong organization skills, attention to detail, critical thinking, multitasking, desire to learn new techniques and contribute to pioneering projects in a fast-paced working environment

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company. If you would like to request an accommodation for medical or religious reasons, you may do so at workplace_adjustment@lilly.com.

At Lilly we strive to ensure our employees are part of a team that cares about them and our shared purpose of making life better for those around the world. How do we do this? We continue to look for ways to include, innovate, accelerate and deliver while maintaining integrity, excellence and respect for people.​ We hope that you seek to join us on our journey as we create medicine and deliver improved outcomes for patients across the globe!

#WeAreLilly

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