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Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us .

About Bristol-Myers Squibb

At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science. In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

The new Bristol-Myers Squibb research site in Cambridge Crossing will help us continue to deliver on our mission, positioning the company and our scientists in the heart of a vibrant ecosystem of world-class science, innovation and business opportunities.

The Mechanisms of Cancer Resistance Thematic Research Center at BMS is one of the fundamental research and early development engines delivering oncology therapeutics to patients. The scientists at this state-of-the-art research and development site in Cambridge focus on novel tumor intrinsic targets and pathways for tumors that are refractory to current Immuno-Oncology and Oncology therapies and implement our discovery platforms across all of our therapeutic areas of focus. We are a fully integrated drug discovery through translational and early clinical development organization which exploits state-of-the-art in vitro, in vivo and ex-vivo models of cancer biology to identify and validate targets. We partner closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials. We are optimally positioned to complement the world-class translational expertise, biology and leading academic research centers in the area.

Position Summary

We are seeking an experienced individual with oncology translational expertise to join the Translational Research team within the Mechanisms of Cancer Resistance Thematic Research Center (MoCR TRC) at Bristol-Myers Squibb in Cambridge, MA. The qualified candidate is highly motivated, interactive, and creative scientist and has the ability to work across a highly matrixed organization to advance programs from candidate optimization through IND enabling activities and ultimately to Clinical Proof of Concept studies. This individual will be dedicated to designing scientific studies and delivering data that impact clinical decision-making for our programs. The candidate will explore patient stratification, drug combination, and/or biomarker concepts and execute bench studies that delivering data for MoCR TRC programs.

Detailed Position Responsibilities

• Develop biomarker, pharmacodynamic and target engagement assays.

• Use current and new techniques to address drug mechanism of action and sensitivity/resistance studies.

• Familiarity with various in vitro oncology models/assays in order to explore drug combination studies and indication selection.

• Utilize a variety of primary patient samples for assay development and drug mechanistic studies.

• Interact with project teams and contract laboratories for design and oversight of molecular, cellular and/or in vivo studies.

• May be responsible for co-authoring non-clinical pharmacology study reports and scientific publications.

• Expected to understand departmental goals and development processes.

• Execute experiments independently, troubleshoot as needed, interpret and discuss data.

• Utilize excellent communication and interpersonal skills. Communicate via email, meetings and reports.

Basic Qualifications:

• Bachelor's Degree

• 7+ years of academic and / or industry experience

Or

• Master's Degree

• 5+ years of academic and / or industry experience

Or

• Ph.D. or equivalent advanced degree in the Life Sciences

• No experience necessary

Desired Experience

• BA or MA with 5-7 years of cumulative research experience. At least 2-5 years in the field of molecular / cell biology, translational research or another relevant field is desired. At least 2-5 years of industry experience in drug discovery or translational research in pharma or biotech setting desired.

• Experienced in the design and development of cell-based assays using various drug modalities including but not limited to small molecules and antibody-drug conjugates.

• Experience working with a variety of primary human tissue samples ex vivo such as whole blood, serum/plasma, tumor biopsies, and circulating tumor cells.

• Experience performing laboratory work, including handling cell cultures and performing analysis of protein and DNA/RNA samples using a variety of methodologies including but not limited to: flow cytometry, MSD/ELISA, Luminex, RNAi, CRISPR, qPCR and primary cell isolation, culture and functional assays.

• Ability to conduct experimental work independently, with accurate, detailed record-keeping.

• Ability to efficiently manage and prioritize multiple projects, coordinating in-house research with collaborative work.

• Ability to summarize and interpret scientific data in a clear, concise, and accurate manner.

• Excellent oral and written communication skills. Ability to communicate well with peers and supervisors.

• Strong problem-solving skills and understanding of relevant scientific principles.

• Ability to be flexible in case of changing priorities.

If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers

With a single vision as inspiring as Transforming patients' lives through science™ , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com . Visit careers.bms.com/ eeo -accessibility to access our complete Equal Employment Opportunity statement.

BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

Company: Bristol-Myers Squibb

Req Number: R1582275

Updated: 2024-06-21 03:31:02.148 UTC

Location: Cambridge Crossing-MA

Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.