Pfizer Senior Scientist, Liver Metabolism in Cambridge, Massachusetts

The Internal Medicine Research Unit (IMRU) is committed to finding cures for cardiovascular disease, metabolic diseases and related complications. The Metabolism group is part of IMRU and focused on identifying novel therapies to improve metabolic homeostasis in patients afflicted with these diseases. Our goal is to build a research team of driven scientists focused on developing a deep mechanistic understanding of the metabolic pathways driving Nonalcoholic Steatohepatitis (NASH), obesity, diabetes and cardiovascular disease. The aim is to recruit a scientifically and technically strong research scientist proficient in in vivo and in vitro metabolic research models.

Responsibilities

The successful candidate is expected to possess strong technical skills in the areas of rodent handling, dietary models of obesity and diabetes and experimental design. Proficiency in cell culture techniques is desired and experience with primary hepatocyte culture is preferred. An advanced understanding of the underlying causes of metabolic disease, hepatosteatosis and basic metabolic pathways is essential.

Successful candidates will be expected to:

  • Perform in vivo experiments to address key mechanistic and pharmacological scientific questions.

  • Have experience with rodent handling, dosing and mouse genetics.

  • Be proficient with cell culture technique. Primary hepatocyte cell culture experience is preferred.

  • Apply scientific and technical expertise to experimental design and the interpretation of results.

  • Have basic laboratory skills in the area of quantitative-PCR, molecular biology, western blotting, biochemical assays, molecular biology and rodent genetics.

  • Maintain a 'cutting edge' awareness of preclinical scientific and technical developments.

  • Ability to present at both internal and external meetings

Basic Qualifications

  • PhD with a minimum of 2 years of post-doc experience, with a successful track record of scientific achievements through scientific publications and presentations.

Preferred Qualifications

  • Possess strong written/verbal communication skills and ability to effectively collaborate with scientists working in other disciplines including neuroscience, chemistry, drug metabolism, drug safety and clinical medicine.

  • Drug discovery experience preferred but is not essential.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

Other Job Details:

  • Last Date to Apply for Job: December 7, 2018

  • Eligible for Employee Referral Bonus

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.