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Novartis Pharmaceuticals Sr. Principal Scientist / Associate Director, Translational M&S in Cambridge, Massachusetts

350203BR Job ID: 350203BR Job Description: 6000! That is the number of associates in the Novartis Institutes for BioMedical Research (NIBR). This division is the innovation engine of Novartis, focusing on powerful new technologies that have the potential to help produce therapeutic breakthroughs for patients. The PK Sciences / Translational Modeling & Simulation group is embedded within the Translational Medicine department of NIBR. Our goal to enable quantitative approaches to rigorous decision making, from target identification to first-in-human studies, and beyond. Novartis has a broad pipeline of therapies across number of disease areas. We are seeking a curious and proactive modeler to apply computational methods to drive the design, characterization, and delivery of these therapies, with a focus on targeted protein degraders (TPDs). Our group is growing, and we hope you will join us as we use computational modeling to generate new insights with both forward and reverse translational approaches. Your responsibilities will include, but are not limited to: • Act as the Translational M&S representative on several targeted protein degrader programs, developing and executing modeling strategy, contributing to project team discussions, and collaboratively guiding decisions such as therapeutic design and dose selection. • Build and apply PK/PD, quantitative systems pharmacology (QSP) models and physiologically based PK (PBPK) models that link drug pharmacology, mechanism(s) of action, and biological outcomes with the aim of informing the human dose. • Contribute to the development of an integrated modeling platform for targeted protein degraders that bridges data and knowledge from preclinical species to patients, partnering with discovery project teams and other groups across TM and NIBR. • Contribute to programs across other therapeutic modalities and diverse disease areas, as needed. Novartis has a broad portfolio with hundreds of drug discovery and clinical development projects, and you will have opportunities for growth and development. • Proactively seek opportunities to increase the impact and awareness of translational modeling through communications with internal and external audiences. • Mentor others and create a constructive culture within own scientific expertise area. • Serve as a M&S subject area expert across PK Sciences and NIBR initiatives and as a Novartis representative in external consortia. \n\n\n\n Position Title: Sr. Principal Scientist / Associate Director, Translational M&S Minimum requirements: What you will bring to the role: • Ph.D. in biology, pharmacology, bioengineering, biophysics, or a related field with 8+ years of industry experience. Candidates with a master’s degree and 12+ years of industry experience will be considered. • Extensive industry experience in quantitative systems pharmacology (QSP), pharmacokinetics and pharmacodynamics (PKPD), and/or physiologically based PK (PBPK) modeling is required. Expertise with discovery-stage PK modeling for small molecule compounds is a plus (e.g., relating ADME properties to in vivo PK; scaling of preclinical PK to human). • Expert level proficiency in core modeling fundamentals is required, including scripting languages (e.g., MATLAB, R), construction of ordinary differential equation (ODE) models, parameter estimation, and data visualization. Experience with standard PBPK software packages such as GastroPlus, SimCYP, or PKsim is a plus. • Demonstrated ability to communicate modeling results to a multidisciplinary audience for collaborative work and/or to facilitate strategy and decision-making. • Fluent in English (oral and written). There are three positions available, and candidates can be considered for all (345275BR, 345276BR, 350203BR). #ModelingAndSimulation #PKSciences #TranslationalMedicineQuants Why Novartis? 766 million lives were touched by Novartis medicines in 2021, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives. We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working. We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible, when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying! Imagine what you could do here at Novartis! Accessibility and Reasonable Accommodations: Individuals in need of a reasonable accommodation due to a medical condition or disability for any part of the application process, or to perform the essential functions of a position, please send an e-mail to tas.nacomms@novartis.com or call +1 (877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Vaccine Policy: While Novartis does not require vaccination at this time, for certain Novartis sites in the US all associates and candidates may be required to either upload an image of their COVID-19 vaccine card demonstrating proof of full vaccination for COVID-19 (or other similar evidence of vaccination) or proof of a negative COVID-19 test taken by the associate or candidate within the past seven days to enter any of our sites and/or customer office or healthcare facility, as well as prior to participating in other work related off-site meetings. Employees working in customer-facing roles must adhere to and comply with customers’ (such as hospitals, physician offices, etc.) credentialing guidelines, which may require vaccination. As required by applicable law, Novartis will consider requests for reasonable accommodation for those unable to be vaccinated. This requirement is subject to applicable state and local laws and may not be applicable to employees working in certain jurisdictions. Please send accommodation requests to Eh.occupationalhealth@novartis.com. Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network Job Type: Full Time Country: USA Work Location: Cambridge, MA Functional Area: Research & Development Division: NIBR Business Unit: Translational Medicine Employment Type: Regular Company/Legal Entity: NIBRI Commitment to Diversity & Inclusion:: The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential. Shift Work: No Early Talent: No

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