Celgene Sr. Scientist, Neuroscience & Imaging in Cambridge, Massachusetts

Description

Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, ​quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries, and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.

Summary/Scope

The Neuroscience Exploratory Biology Lead will have the responsibility for testing novel concepts in cell based drug discovery and target validation for neurodegenerative diseases. The two foundational activities of this group will be to evaluate and implement new cell based screening approaches and, secondly, to develop and support internal collaborations that exploit Celgene expertise in target and lead discovery. The position will have an outward facing role as well, utilizing and leading collaborations with contract research organizations, academic labs, and other drug discovery companies to fulfill the mission of developing new therapeutics for neurodegenerative diseases. The candidate should have demonstrated expertise in applying a variety of genetic and compound based screening approaches in a relevant field of biology. The candidate should be equally adept contributing to our science directly and through leading and guiding others.

Neuroscience at Celgene

The newly established Neuroscience and Imaging TCoE is focused on identifying and developing novel therapies for neurodegeneration. We are concentrating on mechanisms, pathways and targets that are known through genetics to play causative roles in human disease and whose modulation is expected to be disease modifying. A main strategy of our group is to develop partnerships with external leaders in technology and biology to build a world class drug discovery portfolio. In addition, we collaborate within Celgene to utilize our industry-leading understanding of targeted protein degradation to identify and develop innovative medicines for neurodegeneration.

Responsibilities will include, but are not limited to, the following:

  • Establish a lab that will be responsible for developing and testing exploratory approaches in neuroscience drug discovery including assay development, small molecule and genetic screening, target and lead validation.

  • Collaborate with internal groups to exploit Celgene technologies in targeted protein degradation, developing strategies to identify and validate neuroscience targets.

  • Design and produce gene edited cell lines for target validation and screening using in house expertise and coordination of external collaborations.

  • Develop patient relevant systems for target and lead validation including use of iPSC-derived cell types (such as neurons or microglial cells).

  • Participate in the identification and management of neuroscience external partnerships using expertise in drug discovery and neurodegeneration.

  • Represent Celgene’s interests and provide expert scientific input to ongoing drug discovery efforts in neurodegeneration.

  • Represent NSI in internal project discussions to identify opportunities for collaboration across our therapeutic areas and technological functions.

Qualifications:

A Ph.D. in a relevant scientific discipline (eg Neurobiology, Cell Biology, Biological Chemistry) with at least 6 years post-doctoral experience (in academia or industry). Ability to design, perform, and interpret complex in vitro mechanistic studies Proven expertise in design and performance of high throughput cell based screens using small molecule or genetic approaches. Demonstrated ability to develop novel discovery approaches. Experience or strong familiarity with genome engineering and gene editing approaches. Strong organizational skills including the ability to manage several projects simultaneously. Ability to effectively collaborate with colleagues across scientific functions within research as well as with Business Development. Strong communication skills.

#LI-POST

Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.COMMITTED TO IMPROVING THE LIVES OF PATIENTS WORLDWIDE

At Celgene, we seek to deliver truly innovative and life-changing drugs for our patients. Our vision as a company is to build a major global biopharmaceutical corporation while focusing on the discovery, the development, and the commercialization of products for the treatment of cancer and other severe, immune, inflammatory conditions.

“At Celgene, we seek to deliver truly innovative and life-changing drugs for our patients.”

There are more than 300 clinical trials at major medical centers using compounds from Celgene. Investigational compounds are being studied for patients with incurable hematological and solid tumor cancers, including multiple myeloma, myelodysplastic syndromes, chronic lymphocytic leukemia (CLL), non-Hodgkin’s lymphoma (NHL), triple-negative breast cancer and pancreatic cancer. As committed as we are to clinical accomplishment, we are equally committed to patient support, which is a guiding principle at Celgene. We believe all who can benefit from our discoveries should have the opportunity to do so. Celgene puts patients first with industry-leading programs that provide information, support and access to our innovative therapies.