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Cell Signaling Technology Scientist – Epigenetics Applications in Danvers, Massachusetts

Cell Signaling Technology, Inc. (CST) is a private, family owned, worldwide leader in the development and commercialization of antibodies, assays and research tools. As a company of scientists for scientists, we have developed XMT® technology, a proprietary method to develop exceptional monoclonal antibodies, PTMScan®, a technology to discover protein post-translational modifications, and PhosphoSitePlus®, an online resource for investigation of post-translational modifications. We are passionate about our role in contributing to the life science industry’s advancing of the human condition through accelerating the discovery and development of innovative therapies for human disease. We are fully committed to developing new research tools to help define the mechanisms underlying cell function and disease, thereby broadly accelerating progress in biomedical research and medicine.

The mission of the Product Development team is to apply rigorous scientific methods to conceptualize, develop and commercialize biological research reagents, including antibodies, assays, and related workflow products, in order to provide customers with research solutions that will accelerate biological understanding, with the ultimate goal of enabling personalized medicine.

We are currently seeking a highly motivated and creative scientist to join a team dedicated to the development of epigenetics-based assays. The candidate will contribute to the development of innovative research tools, with a primary focus on CUT&Tag, CUT&RUN, and ChIP-seq assays. The Scientist will play a central role in overseeing and orchestrating projects from conception through product release. Thus, the ideal candidate will be combining scientific expertise with project management skills and the ability to effectively communicate project requirements throughout the organization.

The successful candidate must have a Ph.D. with a strong background in epigenetics, biochemistry, molecular biology, or cell biology. The candidate must have hands-on experience in one of the above-mentioned assays and downstream qPCR analysis and NG-seq library preparation. Knowledge and experience with other epigenetic assays, single cell assays, or bioinformatics tools (eg. SAMtools, BEDtools, Bowtie, or MACS, and familiarity with Linux and Basic R programming) is a plus. Strong scientific, organizational, teamwork and communication skills are a must.

  • Lead the design and development of assays and protocols and collaborate with team members and other departments to support the development and commercialization of new assay kits and workflow reagents.

  • Collaborate with other research scientists and associates to complete tasks on aggressive timelines to support internal and external customers.

  • Independently design experiments and analyze experimental data and communicate results to the team and supervisor.

  • Independently test antibody and reagent performance in epigenetic-based assays. Techniques include cell culture, chromatin IP, CUT&RUN, CUT&Tag, qPCR, and DNA sequencing library preparation.

  • Identify, analyze, and troubleshoot technical issues relating to antibody and reagent performance in the epigenetic-based assays.

  • Provide support to colleagues in the commercial organization by reviewing datasheets and technical literature, generating scientific content for webinars and other marketing collateral, and hosting technical training sessions for internal customers.

  • Attend relevant scientific conferences to support on-market CST products and identify new areas for assay development.

  • Engage directly with internal and external customers to provide technical assistance via email and phone. Troubleshoot unexpected results and assist with experimental design questions.

  • PhD in a biological science (e.g. Molecular Biology, Cell Biology, Biochemistry or Biotechnology).

  • Hands-on experience with ChIP, CUT&RUN, or CUT&Tag assay.

  • Experience with NG-sequencing and data analysis.

Preferred Qualifications

  • 2+ years of post-graduate laboratory experience.

  • Experience with other epigenetic-based assays (e.g. ATAC-seq, CLIP-seq).

  • Experience with single cell assays.

  • Strong organizational skills and attention to detail.

  • Ability to work independently with a collaborative mindset.

  • Ability to multi-task effectively and manage multiple priorities at one time.

  • Strong verbal and written communication skills and ability to thrive in a team environment.

  • Familiarity with bioinformatics tools or Python programming is a plus.

Cell Signaling Technology, Inc. is committed to providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, national origin, age, disability, genetic information, status as a veteran or as a member of the military or status in any group protected by applicable federal or state laws.


All resumes submitted by search firms/employment agencies to any employee at Cell Signaling Technology, Inc. via email, the internet or in any form and/or method will be deemed the sole property of CST, unless such search firms/employment agencies were engaged by CST for this position and a valid agreement with CST is in place. In the event a candidate who was submitted outside of the CST agency engagement process is hired, no fee or payment of any kind will be paid.

ID: 2021-1474

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Street: 3 Trask Lane