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Johnson Matthey Associate Director, Chemical Development in Devens, Massachusetts

Associate Director, Chemical Development

Location US - Devens, MA

Sector Health

Requisition Number 12639

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Johnson Matthey (‘JM’) is a global leader in science that enables a cleaner and healthier world. With over 200 years of sustained commitment to innovation and technological breakthroughs, we improve the function, performance and safety of our customers’ products. Our science has a global impact in areas such as low emission transport, pharmaceuticals, chemical processing and making the most efficient use of the planet’s natural resources. Today more than 14,000 Johnson Matthey professionals collaborate with our network of customers and partners to make a real difference to the world around us.

We have an exciting leadership opportunity at our facility in Devens, MA. The Associate Director, Chemical Development will oversee a group of process development chemists to deliver on JM’s portfolio of Originator and Generic active pharmaceutical ingredient (API) projects.

The Chemical Development organization is responsible for designing efficient, robust, and scalable processes that can be moved rapidly from the laboratory to the manufacturing plant. This includes synthetic route evaluation, process development, process characterization, technology transfer and process performance qualification (PPQ). The group works closely with Analytical Development, Solid Form Sciences, Manufacturing Operations, and Quality to support the design and execution of chemical manufacturing processes across all phases of clinical development through to commercial launch, as well as commercialization of generic APIs.

The successful candidate will be responsible for guiding the chemical development team by providing mentorship, technical guidance, and growth opportunities to scientific staff. This role will lead the day-to-day operations of teams of Chemical Development scientists across sites with a focus on synthetic route design, optimization, characterization, process transfer and scale-up. This will require an expert level of understanding of API development and cGMPs, including API SM and mutagenic impurity control strategies, as well as the ability to build and sustain high-performing teams. As a strong communicator, the Associate Director will partner with Regulatory Affairs for the preparation of regulatory filings as well as with other cross-functional leaders both locally and globally.

Key Responsibilities

  • Responsibilities span all areas of development including Commercial Process Development, Process Characterization, Technology Transfer & Process Performance Qualification (PPQ) / Validation.

  • Develop industrially relevant and reliable procedures to control the purity, polymorphism, particle size distribution and bulk properties of API by means of crystallization design, particle engineering, milling etc.

  • Actively ‘directs research’ via leadership presence in the R&D labs, scale-up lab and plant in addition to scientific reviews & external partner engagement

  • Ensures that staff performance & career development are effectively managed

  • Ensures that staff are qualified by education, experience and/or training to successfully perform their professional duties to the highest standards

  • Authors, reviews and/or approves technical reports and regulatory documents

  • Authors, reviews and/or approves departmental guidance documents or SOPs

  • Applies knowledge of GMP and technical problem solving to support scale-up and tech transfer activities across the manufacturing network

  • Oversees the design & execution of appropriate scale-down models for key unit operations & reactions

  • Organizes or participates in departmental committees to ensure that industry best practices are applied

  • Routinely leads and/or contributes to risk assessments, Technical Review Gate meetings and Phase Reviews to advance the portfolio

  • Participates in resource and/or budget planning

  • Informs, consults & advises senior leadership appropriately

  • Identifies and drives Life Cycle Management opportunities including cost of goods and plant cycle time reductions as well as opportunities for disruptive innovation across the portfolio

  • Works with the JM Technology Center and R&D groups in Life Sciences Technologies as well as our partners in Manufacturing to advance and implement new synthetic methods and technologies (including chemo-catalysis, bio-catalysis, modelling, electrochemical synthesis & flow chemistry)

  • Promote & foster industry – academia collaborations to advance JM’s technology platforms or portfolio

  • Promotes the relentless pursuit of innovation and a continual learning culture

    Are you the ideal candidate?

  • PhD in Organic Chemistry

  • 10+ years of academic, post-doctoral or pharmaceutical industry experience

  • Extensive experience in process development

  • Possesses ability to lead, coach and develop a team of multiple experience and skill levels. Exhibits an adaptive management style with an ability to positively resolve conflict

  • Demonstrates strong analytical, written and verbal communication skills. Possesses the ability to write clear and concise technical reports, presentations, and business correspondence

  • Strong business acumen

  • Sound knowledge of current Good Manufacturing Practices (cGMP)

  • Ability to define problems, collect relevant data, recognize patterns, and draw conclusions from disparate information streams. Makes well informed decisions in a timely manner

  • Experience in working in a multi-disciplinary team environment

  • Proven track record of scientific excellence through presentations at conferences and publication of peer reviewed manuscripts.


Johnson Matthey is an Equal Opportunity Employer. Johnson Matthey does not discriminate on the basis of race, color, religion, sex, national origin, age, disability, genetic information, citizenship, veteran status, or other characteristic protected by law.