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Takeda Pharmaceuticals Director, Head of US Medical Project Management Office in Lexington, Massachusetts

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Job Description

About the role:

Join Takeda as a Director, Head of US Medical Project Management Office where you will lead the US Medical Project Management Office that provides core and fit-for-purpose support to the US Medical Therapeutic Area Franchises. This role will require close partnership between US Medical TA Franchise Heads and Functional leaders to deliver on achieving process efficiency, standardization, problem solving best practices and ingraining a cultural mindset of continuous improvement. As part of the US Medical team, you will report to Head of US Medical Operations and Chief of Staff. This is a hybrid role, primarily based on the Lexington, MA campus, with occasional need to travel to the Cambridge, MA campus.

How you will contribute:

Specific role elements include:

  • Line management of the USM TA Project Management team

  • Partnership with TA Medical Franchise Heads to implement and optimize the Medical Unit model according to TA and individual product needs.

  • Development and management of key project management tools and systems that support cross-functional Medical Units to plan, operationalize and execute on medical strategies

  • Partnership with Finance, US Medical TA leadership and Business Operations to manage US Medical's direct/portfolio-related budget, including forecasting/planning for MRP/MYC, and ongoing tracking of actuals vs. plan targets

  • Lead several USM-wide forums intended to promote best practices and information-sharing across therapeutic area and functional stakeholders

  • Lead strategic initiatives and projects according to USM business needs (e.g., process optimization or standardization, system implementation, organizational design initiatives.).


PMO Line Management

  • Manage USM TA Program Management team. This includes:

o Providing clear direction on team remit

o Defining appropriate work allocation in alignment with TA or project complexity

o Assurance of quality work product

o Delivery of equitable and transparent performance management including individual development, establishing PMO competency model in alignment with USM Core Competences and Takeda's leadership behaviors

o Recruiting talent and onboarding team members with appropriate Medical Affairs and PMO training

  • Be an escalation point for TA Medical teams or other USM leadership to address team allocation or performance as necessary.

Fosters Transparent Communication and Builds Relationship Among Key Stakeholders

  • Orchestrate involvement of functions/individuals in relevant communications, decisions and working groups. Distills outcomes from leadership meetings and provides recommendations for effective operational execution.

  • Partner with USM TA Medical and Functional Heads, as well as other USM stakeholders to ensure appropriate TA project management support to deliver TA medical strategies.

  • Lead the Cross-TA Forum, an educational US Medical-wide forum intended to promote best practices across therapeutic areas and functions, including aligning with USM Leadership on relevant topics, meeting facilitation and execution.

  • Build and maintain a network within the broader Takeda enterprise (Global Medical, R&D, USBU) to bring best practices to US Medical

Budget Oversight and Management

  • Partner with Finance and Business Operations to oversee all TA/product related budget management activities (forecasting, planning, monitoring, reporting).

  • Oversee Project Managers to accurately and efficiently support the Mid-Range Plan, Mid-Year Commitment and Latest Best Estimate forecasting and planning cycles.

  • Provide strategic input to any discussions related to variance or trade-offs at portfolio or TA-level, with in-depth knowledge of TA/product level tactics and related spend.

Performance Monitoring and Reporting

  • Define annual TA Project Management key objectives and KPI's in partnership with TA Medical Teams, ensures clarity in expected role and deliverables for USM TA Project Management team.

  • Design and deliver reports that meet the USM Leadership and other key business stakeholders' information needs at the portfolio, TA and product levels.

  • Ensure regular reporting (e.g., key product dashboards, financial aspects) are delivered with high quality and that TA Project Managers contribute to or deliver TA special assignments as assigned.

Project and Program Management Excellence

  • Identifies and implements scalable and consistent reporting methods to transparently inform on key TA or medical products.

  • Creates and maintains a USM Project Management Center of Excellence to optimize project management standards and best practices within USM including project management methodology and systems. Holds team accountable for working within these standards.

Strategic Initiatives and Projects

  • Lead cross-functional projects to optimize the US Medical Unit model or other elements of US Medical operations (e.g. process improvement or standardization initiatives)

  • Leads and oversees the work of cross-functional workstreams, including development of project vision and scope, tactical plan, budget, resource allocation and risk mitigation strategies.

Technical/Functional (Line) Expertise

  • Comprehensive understanding of the pharmaceutical industry and regulations governing medical functions within industry activities and medical regulatory process.

  • Significant experience in drug development and project management.

  • Strong Business and Financial acumen

Decision-making and Autonomy

  • Decision-making scope:

o Accountable for decision making in USM TA Management line

o Ability to seek diverse input from multiple stakeholders to drive innovative solutions

o Ability to incorporate feedback and ensure decisions are made swiftly to yield flawless execution

  • Accountable for allocating USM TA Program Management staff to deliver TA Medical strategies and overarching USM vision and strategy


  • Work in a highly matrixed ecosystem with a high degree of complexity

  • Foster solution-oriented thinking by creating a culture of performance, accountability, simplicity, empowerment, external orientation and curiosity

  • Effectively implements change management efforts to support process optimizations and a positive US Medical culture

  • Effectively negotiates and collaborates with business partners and demonstrates the ability to resolve conflict in a constructive manner

  • Ability to build relationships and guide clarity on the TA PM remit and support of US Medical Therapeutic Areas with other interfacing Takeda functions, including but not limited to Global Medical Affairs, and the US Business Unit.


  • Visionary and forward thinking with the ability to influence and effectively implement continuous innovation

  • Comfortable challenging the status quo and bringing forward innovative solutions

  • Develop and implement business solutions based on trends, needs, opportunities and market direction within pharmaceutical industry

  • Identify areas for process and systems innovation and implement change that will enhance the overall effectiveness of the team

Minimum Requirements/Qualifications:


  • Bachelor's Degree science or business-related field required, advanced science or business degree preferred

Knowledge & Experience

  • Minimum of 10 years of detailed and in-depth pharmaceutical industry experience and drug development in all phases of development with experience within related functions (e.g., Medical Affairs, Clinical Operations, Regulatory, CMC, Marketing, Commercial)

  • Minimum of 8 years of experience as a project/program manager leading complex pharmaceutical project deliverables in a multi-disciplinary, global environment.

  • Experience leading global or regional cross-functional teams spanning drug development life cycle with emphasis on late-phase (i.e., Ph 3-4) and post-marketing development (e.g., through Patent Exclusivity expiration).

  • Experience with legal, compliance, and regulatory guidelines related to the conduct of a variety of types of research trials in the pharmaceutical industry.

  • Knowledge of pertinent external guidelines related to research and publications, and current standards of practice.

  • Strong business and financial acumen with previous experience managing complex budgets

  • Minimum of 8 years of line or matrix management experience.

Leadership Skills and Behaviors

  • Matrix project leadership and proven management skills are required.

  • Expert project and/or program management skills.

  • Creates optimal teaming environment to successfully support TA Project Team and deliverables in accordance with integrated TA medical plans and strategies.

  • Ability to manage a team; solid judge of talent with the ability to develop individual team members, establish clear performance expectations with ongoing constructive feedback, ability to make difficult talent decisions.

  • Solid influencing skills and ability to negotiate in a matrix environment to optimize development and address barriers.

  • Ability to problem-solve and identify appropriate solutions.

  • Highly effective written and verbal communication skills, including strong presentation skills.

  • Ability to lead business process transformation and implement organizational culture change.

  • Ability to drive decision-making within cross-functional team structures.

  • Simultaneous management of multiple tasks of varied complexity.

  • Flexibility, tolerance and diplomacy to best manage change and differing opinions.

  • Excellent organizational skills

  • Proven skills in negotiation, influencing without authority, managing through ambiguity, and working diplomatically through conflict.

  • Excellent knowledge of all MS Office tools to effectively capture and communicate project information


  • Hybrid-role, based in Lexington, MA. Must be able to attend in-person meetings in Lexington and occasionally in Cambridge, MA, as business necessitates.

  • May travel 10% of time, primarily within US with occasional international travel.

What Takeda can offer you:

  • Comprehensive Healthcare: Medical, Dental, and Vision

  • Financial Planning & Stability: 401(k) with company match and Annual Retirement Contribution Plan

  • Health & Wellness programs including onsite flu shots and health screenings

  • Generous time off for vacation and the option to purchase additional vacation days

  • Community Outreach Programs and company match of charitable contributions

  • Family Planning Support

  • Flexible Work Paths

  • Tuition reimbursement

More about us:

At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.

Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

This position is currently classified as "hybrid" in accordance with Takeda's Hybrid and Remote Work policy.

In accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply.

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.


Lexington, MA

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Time Type

Full time