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LogicBio Senior Scientist, In Vivo Pharmacology in Lexington, Massachusetts

Sr. Scientist, In Vivo Pharmacology

About Us

LogicBio is a company dedicated to extending the reach of genetic medicine with pioneering targeted delivery platforms. Our GeneRide? platform enables the site-specific integration of a therapeutic transgene in a nuclease-free and promoterless approach by relying on the native process of homologous recombination to drive lifelong expression. In addition to GeneRide, LogicBio is developing its next generation capsid platform for use in gene editing and gene therapy. Headquartered in Lexington, Mass., we are committed to developing medicines that will transform the lives of patients and their families. We aim to ride Smart, Fast and Together for Patients.

The Opportunity

LogicBio is seeking a highly motivated and scientifically rigorous researcher to join our in vivo pharmacology group at the Sr. Scientist level. The successful candidate will represent the pharmacology line function at project teams providing expertise in in vivo pharmacology and be the key driver for preclinical development of pipeline programs, including identifying/characterizing animal disease models, designing, performing and summarizing PK/PD/Efficacy studies of lead candidates. If you share our passion and sense of urgency for finding a lasting cure for patients, and are looking for a dynamic, collaborative and fulfilling work environment, we invite you to join our team.

Primary Responsibilities

  • Lead/co-lead new indication pipeline projects providing strategic, scientific and technical input and driving the project from conception to IND-enabling activities

  • Leverage broad scientific background to identify, generate and characterize the most suitable disease animal models to support project progression

  • Independently design, develop and execute in vivo, ex vivo and in vitro studies to meet project needs, including target validation, Mechanism of action investigations, comparative pharmacology studies for candidate selection, and IND-enabling Pharm/Tox studies

  • Work with external CRO to expand the in vivo capacity

  • Manage and coach junior scientific associates

  • Prepare, review and deliver scientific findings for internal/external use

  • Keep accurate records of research activities and experimental details

Qualifications

  • PhD in biology, pharmacology, or related disciplines with 3-5 years of post-graduate research experience. Or MS with >5 years of experience in in vivo research.

  • Highly skilled in various in vivo techniques: colony management, handling, dosing (IV, PO, IP), blood collection (tail vein, submandibular and retro-orbital), anesthesia, euthanasia, and necropsy.

  • Experience in gene therapy and/or gene editing is highly desired.

  • Experience in liver-related monogenetic disease models and/or rodent surgery experience is a plus.

  • Proficiency in molecular biology (e.g. ELISA, Western blot, PCR/qPCR, etc.) and cellular biology (cell-based assays, primary and cell line culture) techniques required

  • Proven track record of critical scientific thinking, ability of multi-tasking, strong analytical and problem-solving skills

  • Excellent interpersonal and collaborative skills, and the ability to work both independently and as part of team

  • Flexibility and aptitude for learning with a passion to drive cutting-edge science

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