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Karyopharm Therapeutics Inc. Biostatistician in Newton, Massachusetts

As a Karyopharmer, reporting to the Associate Director, Biostatistics you will positively impact patients’ lives by:

  • Be accountable for all statistical aspects of protocols and regulatory submissions for assigned clinical studies.

  • Work with clinical, pharmacovigilance, and regulatory personnel in preparation of statistical documents (e.g. statistical analysis plans) and analyses (e.g. safety and efficacy analyses) to support DSMB/DMC meetings, Development Safety Update Reports, and investigative brochures.

  • Work with data management personnel in the preparation of data sets that are of high quality and in usable format.

  • Work with medical writing personnel in preparation of clinical study reports and other regulatory documents including NDA

  • Work with publications and data analytics personnel in the preparation of meeting abstracts/presentations and analytical reports of preliminary data from ongoing clinical studies.

  • Proactively mentors and trains subordinates to continually improve processes and procedures in support of internal and external customers.

  • Guide team in the design and analysis of clinical studies using appropriate and innovative statistical methods.

  • Review draft presentations and training materials, including posters and slide decks, according to deadlines.

You will rock this role if you bring:

  • M.S.or Ph.D. in Statistics, Applied Mathematics or related fields

  • Bachelor’s degree in Mathematics

  • Demonstrated ability to effectively contribute to the statistical aspects of clinical protocol design, data interpretation, review and reporting of results for multiple studies and projects.

  • Practical experience with application of advanced statistical methodologies to clinical trial design/analysis and with regulatory reporting/submissions.

  • Strong analytical skills and demonstrated experience in gathering, interpreting and analyzing data in clinical research and drug development.

  • Strong written verbal and written communication skills.

  • Ability to communicate statistical information to non-scientists, willingness to educate internal team.

Our Karyopharmers live and demonstrate our ICURE values every day!


Karyopharmers are passionately driven in our mission to positively impact patients’ lives and defeat cancer! This is personal, and we approach every challenge fiercely and tenaciously, but with enthusiasm, empathy, and passion. The work we do is both inspiring and life-changing. It requires the most diverse, the most unique, and the most authentic team in the industry. We are 400+ cancer driven conquerors, across the globe, with a strong sense of our values and our purpose. We are innovators, disrupters, and collaborators, and we challenge the norm and do things differently. At Karyopharm you will have the opportunity to do well by doing good, while learning and growing along the way. We invite you to join us and make your own personal contribution to our mission!

What We Offer:

In addition to our exciting, supportive, and intellectually challenging global workspaces(s), Karyopharmers enjoy a comprehensive and generous benefits package (active on day one) that makes them more productive and contributes directly to the development of their professional skills.

  • A fun, collaborative, work environment

  • A culture of employee engagement, diversity, and inclusion

  • Competitive salary, bonus, and generous equity offerings (Stock options and RSU’s-at time of offer and annual awards) – we are partners in prosperity!

  • Peace of mind through best in class medical (deducible paid by KPTI), dental, vision, disability, and life insurance, parental leave, a matching 401k program (immediate vesting), and tuition reimbursement.

  • Generous PTO and Holidays – we encourage you to recharge and spend time with family and friends.

  • Ample opportunities to learn and take on new responsibilities in a fast-paced, and patient focused company. (tuition reimbursement, management development programs, and a variety of reward and recognition programs)

  • Cell phone allowance

*Karyopharm requires all employees to be fully vaccinated against the Covid19 virus at the time of employment

  • This position is eligible for remote/hybrid working arrangement (may work from home/virtually; may also work hybrid on-site-virtual as required/approved by hiring manager.



ID: 2022-1999

Street: 85 Wells Ave.