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Karyopharm Therapeutics Inc. Senior Scientist/Principal Scientist, Research & Development in Newton, Massachusetts

The Senior Scientist/Principal Scientist, Research & Development at Karyopharm is responsible for integrating basic science, translational research and clinical development objectives into a comprehensive strategy to achieve the company’s scientific objectives. Key responsibilities include the planning, implementation, and scientific oversight of collaboration research activities in support of the company’s scientific objectives. In this role, you will be is directly involved with development of Karyopharm drug candidates in close communication and collaboration with investigators, academic researchers and internal stakeholders and participates in writing, reviewing and approving various abstracts, presentations and publications for scientific meetings and other internal and external communications. This position is responsible for leading relationships with key pre-clinical and clinical investigators that have a stake in Karyopharm outcomes and for championing scientific communications inside and outside of Karyopharm. May lead cross-functional team in the Research and Translational Medicine Department. A small portion of responsibilities include laboratory work.

PLEASE NOTE: The successful candidate must reside in the Boston, MA area


  • Plan, implement and oversee scientific aspects of specific collaboration activities relevant to Karyopharm research and development objectives

  • Design and analyze in vivo studies of disease models in animals to be conducted with CROs.

  • Provide scientific and technical support to investigators, collaborators and internal stakeholders

  • Collaborate with Biology, Translational Research, Toxicology, Clinical Operations, Data Analytics and other Karyopharm functions to support preclinical and clinical research objectives

  • Present data at key scientific meetings/conferences regarding company's products and research

  • Develop in-depth knowledge of therapeutic areas, current medical practice and industry regulations in order to ensure best practice across all activities

  • Laboratory work requires the design, conduct and analysis of in-vitro experiments to facilitate drug discovery and development of Karyopharm’s programs and the performance of gene expression and functional studies while using various molecular biology and biochemical methods as cell transfection, knockdown experiments, isolation of DNA, RNA and performing qPCR, Immunoblots and immunofluorescence assays

  • Laboratory work will be conducted independently and/ or while mentoring others

  • PhD degree in oncology, cell biology, molecular biology or a related discipline

  • 5+ years of working experience in a pharma, biotech or academic setting

  • Experience in standard cellular and molecular biology techniques (Cell culture, ELISA, Cell-based assays, Immunofluorescence, Western blotting, Microscopy, RNA/DNA isolation, qPCR)

  • Strong analytical and problem-solving skills to conduct experiments related to drug discovery and development projects

  • Excellent written and oral communication skills

  • Requires strong attention to detail in composing and proofing materials, establishing priorities, scheduling and meeting deadlines

  • Must be able to work in a fast-paced environment with demonstrated ability to juggle multiple competing tasks and demands

  • Ability to work successfully within a cross-functional team and in a matrixed environment where influence without authority is critical

  • Ability to interact with investigators, vendors, and internal colleagues

  • Ability to complete tasks to deadlines and resolve/elevate problems in a timely manner

Karyopharm Therapeutics is a global commercial-stage pharmaceutical company focused on the discovery and development of novel first-in-class drugs directed against nuclear transport targets for the treatment of cancer and other major diseases.

ID: 2020-1712

Street: 85 Wells Ave.