Job Information
Alloy Therapeutics Director, In Vitro Screening & Pre-clinical Development in Waltham, Massachusetts
The Company
We are Alloy Therapeutics —a biotechnology ecosystem company empowering the global scientific community to make better medicines together. Through a community of partners, we democratize access to pre-competitive tools, technologies, services, and company creation capabilities that are foundational for discovering and developing therapeutic biologics. The company facilitates affordable, non-exclusive access to the entire drug discovery community from academic scientists, small and medium biotech, to the largest biopharma. At Alloy, we believe our industry should compete on getting the best drugs to patients as quickly as possible, not exclusive access to the best platforms. As a reflection of our relentless commitment to the scientific community, we reinvest 100% of our revenue in innovation and access to innovation. MAY THE BEST DRUG WIN.
Alloy is headquartered in Waltham, MA with additional labs in Cambridge, UK; Basel, Switzerland, and Athens, GA. Successful members thrive in our shared culture of accountability, deliberate trust, and open communication. As a team we aspire to work together to exceed expectations and collectively contribute across the global organization to always maintain our nimble, startup culture.
This is an on-site and full-time position in Waltham, MA. At Alloy, we have an ethos of “Mentorship-By-Apprenticeship” in all of our positions. We strive to have workers in the office when needed to interact organically and face-to-face. Of course, as a lab-based operation, our cells and animals grow 7 days a week, 365 days per year. We respect and value our colleagues for their hard work that requires them to be in the lab every day. We ask our people who have more flexible accommodations, like this position, to appreciate their colleagues who have less flexibility. We are all one team!
The Team
Alloy’s Translational Research team collaborates with drug discovery partners to conduct in vitro studies on therapeutic candidates across diverse modalities. Our team delivers comprehensive functional screening and characterization of biologics to support discovery and selection of lead candidates. Primary modalities are monoclonal and multispecific antibodies, and TCR-mimic antibodies but also include cell therapies and genetic medicines. As Alloy Tx enters its next phase of growth, we are expanding our capabilities to include mechanistic studies that enhance preclinical development and further advance our translational research efforts.
The Role
We are seeking a highly experienced Director, In Vitro Screening & Pre-clinical Development to lead our in vitro screening, assay development, and translational research efforts. This role will be responsible for designing and implementing high-throughput and mechanistic in vitro assays while integrating translational insights to bridge discovery and preclinical research. The ideal candidate will bring deep expertise in immunology, cellular and molecular assay development, and mode-of-action studies to support biologics drug discovery programs.
How You’ll Drive Impact
Strategy: Develop and execute an integrated preclinical in vitro screening and translational immunology strategy to support drug discovery and development.
Leadership: Lead and mentor a team of scientists and research associates in assay development, in vitro screening, and translational immunology.
Produce: Design, validate, and implement robust in vitro assays to assess immune cell function, cytokine profiling, receptor-ligand interactions, and mechanistic pharmacology.
Innovate: Stay current with advancements in immunology, assay technologies, and translational research to enhance discovery-to-clinic transition.
Develop: Functional screening assays for biologics and cell-based therapies to support lead optimization.
Principal Responsibilities
Lead and oversee in vitro screening and translational research initiatives.
Actively contribute to laboratory experiments and project execution.
Provide leadership and mentorship to the research team.
Develop research strategies in collaboration with partners
Collaborate with BD to engage in discussions with potential partners
Organize and align team efforts to ensure efficiency and progress.
Ensure timely and successful execution of project milestones according to plan.
Qualifications
You have a Ph.D. in Immunology, Cell Biology, Translational Medicine, or a related field with 8+ years of experience in preclinical in vitro screening and translational research in an industry setting
You have proven expertise in immune cell-based assays, cytokine profiling, high-throughput screening, and mechanistic studies.
You have a strong background in autoimmune, inflammatory, and oncology-related immunology research.
You have experience leading teams and managing projects in a pharmaceutical or biotechnology setting.
You have experience supporting IND-enabling studies and regulatory interactions.
You pay attention to details, and you practice rigorous scientific thinking & clear communication skills
You have sense of urgency, speed, persistence, and organization and prefer a dynamic, fun, and exciting work environment
Ability to work across various US and international time zones
Accommodate occasional travel as needed (<10%)
Taking Care of Our People
We support the individuality of what people need to do outside of work to empower them to do their best at work. While you focus on making better medicine together, we focus on programs and benefits that support a diverse and growing team. Whether you’re single, in a growing family, or nearing retirement, Alloy offers a variety of comprehensive and competitive benefits starting from day one.
Compensation
Competitive base and equity compensation commensurate with level of experience and independence
401(k) company match
Health & Family
Generous personal and family medical, dental and vision benefits with 100% of premiums and deductibles covered
Company-paid disability (STD, LTD) and life insurance
Paid parental leave
Family planning support up to $45,000 (e.g., IVF/PGT, adoption, surrogacy, egg retrieval)
Unique Perks
Unlimited PTO (paid time off) and flexible schedules
Annual stipend for continuing education with commitment to your career through individualized professional development plan
Wellness and Extensive Employee Assistance Program (EAP) including resources for mental wellness
Pay Transparency
At Alloy Therapeutics, we believe in fostering trust and open communication. For this role, the estimated annual base salary range is $180,000 - $211,000, with the final offer based on factors like your experience, skills, and alignment with our needs.
Additionally, this role is eligible for equity compensation, reflecting our commitment to shared success as we work together to make better medicines.
We are proud to offer competitive compensation and benefits, aiming to support our team’s professional and personal well-being. If you have any questions about pay or benefits, we’re here to help.
Alloy Therapeutics is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, national origin, sex, sexual orientation, gender identity, veteran status, disability, or other legally protected status. If you are unable to submit an application because of incompatible assistive technology or a disability, please contact us at recruiting@alloytx.com . We will make every effort to respond to your request for disability assistance as soon as possible.
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