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EyePoint Pharmaceuticals, Inc. Sr. Scientist/Scientist II/Scientist I Formulation Development in Watertown, Massachusetts


Be Seen and Heard at EyePoint Pharmaceuticals

At EyePoint, leadership trusts our employees to get the job done. The patient-centric and award-winning approach we’re taking in business fuels our success for:

  • preventing blindness through vision-saving medications

  • delivering best-in-class proprietary pharmaceutical technologies

  • transforming ocular drug delivery

We See You.

Your wellbeing

Your professional worth

Your future at EyePoint

EyePoint offers robust total rewards in a science-based entrepreneurial culture that empowers curiosity and innovation to help catapult your career. There’s space for every voice and perspective to be heard in our on-site and remote environments where a variety of strengths and diverse backgrounds are connected.

Position Summary

Eyepoint pharmaceuticals is seeking a Formulation Scientist I/Scientist II/Sr. Scientist, based upon years of experience, to join our Research and Product Development group in Watertown MA. This position is reporting to the Manager, Formulations Development. Our department works closely with Operations, Regulatory Affairs, Analytical Development, and Quality control to formulate and manufacture innovative ocular formulations.

The ideal candidate should have a strong background in advanced physical chemistry, pharmaceutics and the use of polymers in ocular delivery. The selected candidate will design and execute experiments to develop and characterize novel ocular formulations, as well as assist in analysis of formulations using analytical techniques as required. The candidate will also be required to manage CDMOs for development and technical transfer of manufacturing activities, including troubleshooting, scale up and optimization of manufacturing processes.

Additional responsibilities involve contributions to any post marketing changes. The qualified candidate will interact with other departments, participate in cross functional teams, contribute to the product development plans, and authorship of publications and pertinent sections of regulatory submissions.

The selected candidate must be a strong team player with excellent communication skills working in a complex cross-functional environment. The candidate must be able to work independently and take initiative by providing input on multiple projects. The candidate must be able to think critically, intellectually curious, and shows resilience and courage to resolve complex formulation and manufacturing problems.

This position is based in Watertown, MA and offers flexible work hours.

Primary responsibilities include, but are not limited to, the following:

Individual responsibilities

  • Develop ocular formulations through all phases of product development.

  • Work on late stage process development of drug product/device combination.

  • Develop novel drug delivery technologies for (small molecules) ocular products

  • Identify and implement improvements to existing EyePoint technologies.

  • Identify and implement solutions to challenges with existing EyePoint products.

  • Build expertise and knowledge around ocular drug product formulations and summarize findings in scientific papers and technical reports.

  • Generate data for project progression and regulatory filings, conduct optimization and process scale up studies.

  • Actively collaborate with the analytical department and our CMOs to develop and perform testing methods and to understand the impact of manufacturing process on product integrity, quality and stability.

  • Scientifically interpret complex data sets and provide sound recommendations for successful product and formulation development.

  • Present experimental plans and data to senior management and CMC, manufacturing and project leadership.

  • Contribute substantively to patent and publication preparation.

  • Maintain knowledge with up-to-date scientific literature in the field of ocular drug delivery.

  • Transfer technical knowledge to CMO for scale up of formulation and process optimization.

  • Provide guidance for other research staff and advise about quality, timeliness and accuracy of work done.

Primary skills and knowledge required include, but are not limited to the following:

  • Solid knowledge of pharmaceutical and engineering principles in solid dosage form development.

  • Understanding of fundamental biopharmaceutical principles.

  • Hands-on experience with physicochemical and analytical techniques such as DSC, TGA, XRPD, HPLC, SEM, PSD, KF, and Dissolution. Understanding of FTIR, NMR, and RAMAN analytical techniques, a plus.

  • Hands on experience with formulation techniques, processing equipment, and unit operations for laboratory, clinical, and commercial manufacturing scales.

  • Strong technical writing skills.

  • Excellent verbal and written communication skills.

  • Ability to multitask and work on a few projects concurrently.

  • Detail-oriented.

  • Team player and ability to quickly adapt to any changes in project priorities.

  • Strong knowledge in formulation development of small molecules is required.

Preferred Qualifications

  • Thorough understanding of polymer chemistry and drug-polymer interaction.

  • Ability to effectively and collaboratively lead and participate in technical team discussions.

  • Direct experience working with CMOs.

  • Experience with a range of dosage forms including solid, semi-solid, and liquids.

  • Experience in extrusion is a plus.

  • Experience with formulation development of class II, III, and IV biopharmaceuticals drugs.

  • Proven ability to apply scientific principles to pre-formulation and formulation development using a rational approach.

  • Leadership experience is a plus.

  • GLP, GMP, and GxP experience is a plus.

  • Knowledge in large molecules/biologics formulations is a plus.

  • Knowledge of injectable drug products is a plus.

Level of Education Required Field of Study:

  • PhD in Pharmaceutical Sciences, Chemical Engineering or related discipline with 3+ years of related industry experience or Masters with 5 years of related industry experience or Bachelor’s with 15+ years related experience.

Envision Your Future

With the exciting energy of a winning culture and an exhilarating pace, we are an ophthalmology company committed to preventing blindness by developing and commercializing innovative therapeutics.

The collective power of our values influences everything we do, and everything we do for you.

  • Success begins with our People

  • Patients First

  • Integrity

  • Results-Driven

  • Innovation

  • Team Focus

  • Diversity & Inclusion

EyePoint Pharmaceuticals is proud to be an equal opportunity employer. We believe that diversity and inclusion among our colleagues is critical to our success as a company, and we seek to recruit, develop, and retain the most talented people from a diverse candidate pool. All applicants will be considered for employment without attention to age, race, color, religion, sex, sexual orientation, gender identity, national origin, veteran, or disability status.


ID: 2023-1326

External Company Name: EyePoint Pharmaceuticals, Inc.

External Company URL:

Street: 480 Pleasant Street